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Literature DB >> 16215642

Molecular genetic analysis for a novel Ael allele of the ABO blood group system.

Qiong Yu¹, Zhi-Hui Deng, Guo-Guang Wu, Yan-Lian Lian, Yu-Qing Su.

Abstract

The ABO blood group is the most important system in clinical transfusion medicine. Previous studies on the genetic base of the common ABO group and some rare ABO subgroups have suggested that the molecular genetic background of the ABO gene in the Chinese population has specific character. In this study, we carried out a molecular genetic analysis of a family with an individual diagnosed as Ael subgroup by serological tests. A novel allele was identified in our A subgroup cases.

Entities: Gene

Mesh：

Substances：
ABO Blood-Group System

Year: 2005 PMID： 16215642 DOI： 10.1007/s10038-005-0308-y

Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172

9 in total

1. Molecular genetic analysis for the Ae1 and A3 alleles.

Authors: Chien-Feng Sun; Lung-Chih Yu; Ing-Ping Chen; Ding-Lun Chou; Yuh-Ching Twu; Wei-Ting Wang; Marie Lin
Journal: Transfusion Date: 2003-08 Impact factor: 3.157

2. Novel ABO blood group allele with a 767T>C substitution in three generations of a Chinese family.

Authors: Guo Guang Wu; Qiong Yu; Yu Qing Su; Zhi Hui Deng; Yan Lian Liang; Tian Li Wei; Tong Mao Zhao
Journal: Transfusion Date: 2005-04 Impact factor: 3.157

3. Molecular genetic analysis of variant phenotypes of the ABO blood group system.

Authors: K Ogasawara; R Yabe; M Uchikawa; N Saitou; M Bannai; K Nakata; M Takenaka; K Fujisawa; Y Ishikawa; T Juji; K Tokunaga
Journal: Blood Date: 1996-10-01 Impact factor: 22.113

4. Polymorphisms at the ABO locus in subgroup A individuals.

Authors: M L Olsson; M A Chester
Journal: Transfusion Date: 1996-04 Impact factor: 3.157

5. An Ael allele-specific nucleotide insertion at the blood group ABO locus and its detection using a sequence-specific polymerase chain reaction.

Authors: M L Olsson; B Thuresson; M A Chester
Journal: Biochem Biophys Res Commun Date: 1995-11-13 Impact factor: 3.575

1 in total

1. Two novel mutations p. L319V and p. L91P in ABO glycosyltransferases lead to A_el and B_el phenotypes.

Authors: Hang Lei; Zhongying Wang; Yuqing Wang; Dong Xiang; Xuefeng Wang; Xiaohong Cai
Journal: Blood Transfus Date: 2020-04-03 Impact factor: 3.443

1 in total

Molecular genetic analysis for a novel Ael allele of the ABO blood group system.

1. Molecular genetic analysis for the Ae1 and A3 alleles.

2. Novel ABO blood group allele with a 767T>C substitution in three generations of a Chinese family.

3. Molecular genetic analysis of variant phenotypes of the ABO blood group system.

4. Polymorphisms at the ABO locus in subgroup A individuals.

5. An Ael allele-specific nucleotide insertion at the blood group ABO locus and its detection using a sequence-specific polymerase chain reaction.

6. Genomic organization of human histo-blood group ABO genes.

7. Systematic analysis of the ABO gene diversity within exons 6 and 7 by PCR screening reveals new ABO alleles.

8. Molecular genetic analysis for Ax phenotype of the ABO blood group system in Chinese.

9. Extensive polymorphism of ABO blood group gene: three major lineages of the alleles for the common ABO phenotypes.

1. Two novel mutations p. L319V and p. L91P in ABO glycosyltransferases lead to A_el and B_el phenotypes.