| Literature DB >> 16214290 |
Nathalie Brouwers1, Kristel Sleegers, Sebastiaan Engelborghs, Veerle Bogaerts, Cornelia M van Duijn, Peter Paul De Deyn, Christine Van Broeckhoven, Bart Dermaut.
Abstract
An intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1), that is located at a well established Alzheimer's disease (AD) locus on chromosome 9q22, was recently associated with increased risk for late-onset AD. We analyzed this polymorphism in two independent AD samples consisting of patients with an onset age 70 years or less, but did not observe statistically significant association. Our study does not support a major role for this UBQLN1 polymorphism in AD patients with an earlier onset of disease.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16214290 DOI： 10.1016/j.neulet.2005.08.064
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046