K R Muthusami1, P Chinnaswamy. 1. The Tamil Nadu Dr. M.G.R. Medical University, Chennai, India. muthusamikr@yahoo.co.in
Abstract
OBJECTIVE: To evaluate the effects of chronic alcoholism on the male fertility hormones and quality of semen. DESIGN: Non-probability purposive clinical study. SETTING: Addiction treatment center and an academic research environment. PATIENT(S): Sixty-six alcoholics free from smoking and drug abuse who consumed a minimum of 180 mL of alcohol per day (brandy and whisky, both 40%-50% alcohol content) for a minimum of 5 days per week for > or =1 year were included. Thirty nonsmoking nonalcoholics were selected as controls. INTERVENTION(S): Before starting the addiction treatment for alcoholics, venous blood and semen samples were collected. MAIN OUTCOME MEASURE(S): Complete blood counts, biochemical parameters, levels of the male fertility hormones FSH, LH, T, PRL, P, and E2 in blood, and semen parameters. RESULT(S): In alcoholics, FSH, LH, and E2 levels were significantly increased, and T and P levels were significantly decreased. No significant change was noted in PRL levels. Semen volume, sperm count, motility, and number of morphologically normal sperm were significantly decreased. CONCLUSION(S): Chronic alcohol consumption has a detrimental effect on male reproductive hormones and on semen quality.
OBJECTIVE: To evaluate the effects of chronic alcoholism on the male fertility hormones and quality of semen. DESIGN: Non-probability purposive clinical study. SETTING: Addiction treatment center and an academic research environment. PATIENT(S): Sixty-six alcoholics free from smoking and drug abuse who consumed a minimum of 180 mL of alcohol per day (brandy and whisky, both 40%-50% alcohol content) for a minimum of 5 days per week for > or =1 year were included. Thirty nonsmoking nonalcoholics were selected as controls. INTERVENTION(S): Before starting the addiction treatment for alcoholics, venous blood and semen samples were collected. MAIN OUTCOME MEASURE(S): Complete blood counts, biochemical parameters, levels of the male fertility hormones FSH, LH, T, PRL, P, and E2 in blood, and semen parameters. RESULT(S): In alcoholics, FSH, LH, and E2 levels were significantly increased, and T and P levels were significantly decreased. No significant change was noted in PRL levels. Semen volume, sperm count, motility, and number of morphologically normal sperm were significantly decreased. CONCLUSION(S): Chronic alcohol consumption has a detrimental effect on male reproductive hormones and on semen quality.
Authors: Yudhishtar Bedi; Richard C Chang; Rachel Gibbs; Tracy M Clement; Michael C Golding Journal: Reprod Toxicol Date: 2019-04-30 Impact factor: 3.143
Authors: A E Karmon; T L Toth; Y-H Chiu; A J Gaskins; C Tanrikut; D L Wright; R Hauser; J E Chavarro Journal: Andrology Date: 2017-02-10 Impact factor: 3.842