| Literature DB >> 16213735 |
Ugo Chiacchio1, Daniela Iannazzo, Anna Piperno, Roberto Romeo, Giovanni Romeo, Antonio Rescifina, Monica Saglimbeni.
Abstract
The synthesis of carbocyclic 2'-oxa-3'-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed.Entities:
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Year: 2005 PMID： 16213735 DOI： 10.1016/j.bmc.2005.09.024
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641