| Literature DB >> 16213726 |
K Suresh Babu1, T Hari Babu, P V Srinivas, K Hara Kishore, U S N Murthy, J Madhusudana Rao.
Abstract
The natural product, chrysin (5,7-dihydroxy flavone), obtained from Oroxylum indicum, exhibits numerous biological activities including anticancer, anti-inflammatory, and antiallergic activities. Three series of chrysin analogues were prepared, in which chrysin and heterocyclic moieties are separated by 3-carbon, 4-carbon, and 6-carbon spacers. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin).Entities:
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Year: 2005 PMID： 16213726 DOI： 10.1016/j.bmcl.2005.09.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823