| Literature DB >> 16213711 |
Yan Shi1, Jing Zhang, Philip D Stein, Mengxiao Shi, Stephen P O'Connor, Sharon N Bisaha, Chi Li, Karnail S Atwal, Gregory S Bisacchi, Doree Sitkoff, Andrew T Pudzianowski, Eddie C Liu, Karen S Hartl, Steven M Seiler, Sonia Youssef, Thomas E Steinbacher, William A Schumacher, Alan R Rendina, Jeffrey M Bozarth, Tara L Peterson, Ge Zhang, Robert Zahler.
Abstract
N,N'-Disubstituted ketene aminals are good bioisosteres of thiourea functional groups. We report the design and synthesis of a novel class of ketene aminal-based lactam derivatives as potent and orally active FXa inhibitors.Entities:
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Year: 2005 PMID： 16213711 DOI： 10.1016/j.bmcl.2005.08.107
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823