Literature DB >> 16213708

Anti-malarial activity of Baylis-Hillman adducts from substituted 2-chloronicotinaldehydes.

P Narender1, U Srinivas, B Gangadasu, Sukla Biswas, V Jayathirtha Rao.   

Abstract

New Baylis-Hillman adducts are synthesized based on substituted 2-chloronicotinaldehydes and screened for their in vitro anti-malarial activity against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. Out of the six new compounds synthesized and screened, 2b, 2c and 2d compounds showed substantial anti-malarial activity.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16213708     DOI： 10.1016/j.bmcl.2005.09.008

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Biological activity of Morita-Baylis-Hillman adduct homodimers in L. infantum and L. amazonensis: anti-Leishmania activity and cytotoxicity.

Authors:  Juliana da Câmara Rocha; Klinger Antonio da Franca Rodrigues; Patrícia Lima do Nascimento Néris; Larisse Virgolino da Silva; Fernanda Silva Almeida; Viviane Silva Lima; Rephany Fonseca Peixoto; Juliene da Câmara Rocha; Fátima de Lourdes Assunção Araújo de Azevedo; Robson Cavalcanti Veras; Isac Almeida de Medeiros; Wagner André Vieira da Silva; Claudio G Lima-Junior; Mário Luiz Araújo de Almeida Vasconcellos; Ian Porto Gurgel do Amaral; Márcia Rosa de Oliveira; Tatjana de Souza Lima Keesen
Journal:  Parasitol Res       Date:  2019-08-07       Impact factor: 2.289

2.  One-Electron Reduction Potentials: Calibration of Theoretical Protocols for Morita⁻Baylis⁻Hillman Nitroaromatic Compounds in Aprotic Media.

Authors:  Amauri Francisco da Silva; Antonio João da Silva Filho; Mário L A A Vasconcellos; Otávio Luís de Santana
Journal:  Molecules       Date:  2018-08-24       Impact factor: 4.411
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.