Literature DB >> 16212909

Novel role and regulation of the interleukin-1 receptor associated kinase (IRAK) family proteins.

Ying Su Huang1, Anna Misior, Li Wu Li.   

Abstract

The interleukin-1 receptor associated kinases (IRAKs) sit at the bottle neck for the Toll-like-receptor (TLR) mediated signal transduction process controlling host innate immune response. However, the exact role and regulation of IRAKs are still in the early stage and not fully understood. This review intends to summarize the recent advancement in this important topic and point out areas that need further intensive investigation.

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Year:  2005        PMID： 16212909

Source DB:  PubMed          Journal:  Cell Mol Immunol        ISSN： 1672-7681            Impact factor:   11.530


  12 in total

1.  Selective role of Nck1 in atherogenic inflammation and plaque formation.

Authors:  Mabruka Alfaidi; Christina H Acosta; Dongdong Wang; James G Traylor; A Wayne Orr
Journal:  J Clin Invest       Date:  2020-08-03       Impact factor: 14.808

2.  Interleukin-1 Receptor-Associated Kinase (IRAK) Signaling in Kaposi Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma.

Authors:  Jedediah Seltzer; Razia Moorad; Jason M Schifano; Justin T Landis; Dirk P Dittmer
Journal:  J Virol       Date:  2020-05-04       Impact factor: 5.103

3.  Association between interleukin-1 receptor associated kinase 1 rs3027898 A/C gene polymorphism and rheumatoid arthritis.

Authors:  Mahdi Atabaki; Mohammad Hashemi; Hamid Daneshvar; Ebrahim Alijani
Journal:  Biomed Rep       Date:  2017-02-09

Review 4.  Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer.

Authors:  Andrei E Medvedev
Journal:  J Interferon Cytokine Res       Date:  2013-05-15       Impact factor: 2.607

5.  Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer.

Authors:  Arthur Y Shaw; Meredith C Henderson; Gary Flynn; Betty Samulitis; Haiyong Han; Steve P Stratton; H-H Sherry Chow; Laurence H Hurley; Robert T Dorr
Journal:  J Pharmacol Exp Ther       Date:  2009-08-05       Impact factor: 4.030

6.  Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) functionally associates with PKCepsilon and VASP in the regulation of macrophage migration.

Authors:  Lu Gan; Liwu Li
Journal:  Mol Immunol       Date:  2009-12-30       Impact factor: 4.407

7.  Cleavage and nuclear localization of the rice XA21 immune receptor.

Authors:  Chang-Jin Park; Pamela C Ronald
Journal:  Nat Commun       Date:  2012-06-26       Impact factor: 14.919

8.  MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury.

Authors:  Cécilia Chassin; Cordelia Hempel; Silvia Stockinger; Aline Dupont; Joachim F Kübler; Jochen Wedemeyer; Alain Vandewalle; Mathias W Hornef
Journal:  EMBO Mol Med       Date:  2012-11-09       Impact factor: 12.137

Review 9.  IRAK-4 inhibitors for inflammation.

Authors:  Zhulun Wang; Holger Wesche; Tracey Stevens; Nigel Walker; Wen-Chen Yeh
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

10.  IRAK2, an IL1R/TLR Immune Mediator, Enhances Radiosensitivity via Modulating Caspase 8/3-Mediated Apoptosis in Oral Squamous Cell Carcinoma.

Authors:  Chih-Chia Yu; Michael W Y Chan; Hon-Yi Lin; Wen-Yen Chiou; Ru-Inn Lin; Chien-An Chen; Moon-Sing Lee; Chen-Lin Chi; Liang-Cheng Chen; Li-Wen Huang; Chia-Hui Chew; Feng-Chun Hsu; Hsuan-Ju Yang; Shih-Kai Hung
Journal:  Front Oncol       Date:  2021-06-23       Impact factor: 6.244
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