Literature DB >> 16212906

Specific control of immunity by regulatory CD8 T cells.

Xiao Lei Tang1, Trevor Rf Smith, Vipin Kumar.   

Abstract

T lymphocytes with dedicated suppressor function (Treg) play a crucial role in the homeostatic control of immunity in the periphery. Several Treg phenotypes have now been identified in the CD4 and CD8 T cell populations, suggesting their down-regulatory function in both human and animal models of autoimmunity, transplantation and tumor immunity. Here we will focus on the CD8 Treg population and their ability to specifically inhibit a pathogenic autoimmune response. This review will detail the current advances in the knowledge of CD8 Treg in the context of antigen specificity, phenotype, MHC restriction, mechanism of action, and priming.

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Year:  2005        PMID： 16212906

Source DB:  PubMed          Journal:  Cell Mol Immunol        ISSN： 1672-7681            Impact factor:   11.530


  24 in total

1.  Splenic CD8+ T cells secrete TGF-beta1 to exert suppression in mice with anterior chamber-associated immune deviation.

Authors:  Liqiong Jiang; Hao He; Peizeng Yang; Xiaomin Lin; Hongyan Zhou; Xiangkun Huang; Aize Kijlstra
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2008-09-17       Impact factor: 3.117

2.  Global expression profiling of peripheral Qa-1-restricted CD8αα+TCRαβ+ regulatory T cells reveals innate-like features: implications for immune-regulatory repertoire.

Authors:  Shaohsuan S Fanchiang; Radu Cojocaru; Mohammad Othman; Ritu Khanna; Matthew J Brooks; Trevor Smith; Xiaolei Tang; Igor Maricic; Anand Swaroop; Vipin Kumar
Journal:  Hum Immunol       Date:  2011-08-17       Impact factor: 2.850

Review 3.  CD8+ Tregs in lupus, autoimmunity, and beyond.

Authors:  Ravi K Dinesh; Brian J Skaggs; Antonio La Cava; Bevra H Hahn; Ram Pyare Singh
Journal:  Autoimmun Rev       Date:  2010-04-10       Impact factor: 9.754

Review 4.  Making sense of regulatory T cell suppressive function.

Authors:  Itay Shalev; Moritz Schmelzle; Simon C Robson; Gary Levy
Journal:  Semin Immunol       Date:  2011-05-17       Impact factor: 11.130

5.  Altered levels of circulating CD8+CXCR5+PD-1+T follicular cytotoxic cells in primary Sjögren's syndrome.

Authors:  Xuwen Zhai; Yanlin Wang; Hui Guo; Zhaojun Liang; Min Feng; Yanyao Wu; Yan Qin; Xiangcong Zhao; Chong Gao; Jing Luo
Journal:  Clin Rheumatol       Date:  2022-02-16       Impact factor: 2.980

Review 6.  Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone mice.

Authors:  Brian J Skaggs; Ram Pyare Singh; Bevra H Hahn
Journal:  Hum Immunol       Date:  2008-09-24       Impact factor: 2.850

7.  CD8+ CD122+ regulatory T cells contain clonally expanded cells with identical CDR3 sequences of the T-cell receptor β-chain.

Authors:  Yusuke Okuno; Ayako Murakoshi; Masashi Negita; Kazuyuki Akane; Seiji Kojima; Haruhiko Suzuki
Journal:  Immunology       Date:  2013-07       Impact factor: 7.397

8.  In vitro and In vivo CD8+ T Cell Suppression Assays.

Authors:  Lu Xie; Guihuan Liu; Yanjun Liu; Yuming Yu
Journal:  Bio Protoc       Date:  2021-05-20

9.  Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment.

Authors:  Karthick Raja Muthu Raja; Lenka Kubiczkova; Lucie Rihova; Martin Piskacek; Pavla Vsianska; Renata Hezova; Ludek Pour; Roman Hajek
Journal:  PLoS One       Date:  2012-11-13       Impact factor: 3.240

10.  In silico investigation into dendritic cell regulation of CD8Treg mediated killing of Th1 cells in murine experimental autoimmune encephalomyelitis.

Authors:  Richard A Williams; Richard Greaves; Mark Read; Jon Timmis; Paul S Andrews; Vipin Kumar
Journal:  BMC Bioinformatics       Date:  2013-04-17       Impact factor: 3.169
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