Literature DB >> 16212232

Antidiabetic stilbene and anthraquinone derivatives from Rheum undulatum.

Sang Zin Choi1, Sung Ok Lee, Ki Uk Jang, Sung Hyun Chung, Sang Hyun Park, Hee Chol Kang, Eun Young Yang, Hi Jae Cho, Kang Ro Lee.   

Abstract

The antidiabetic-activity-guided fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of one stilbene, desoxyrhapontigenin (1) and two anthraquinones, emodin (2) and chrysophanol (3). Their structures were established by chemical and spectroscopic methods. Compounds 1, 2, and 3 inhibited postprandial hyperglycemia by 35.8, 29.5, 42.3%, respectively.

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Year:  2005        PMID： 16212232     DOI： 10.1007/bf02977396

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  10 in total

1.  Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis.

Authors:  Tuy An Trinh; Dahae Lee; Seonju Park; Seung Hyun Kim; Jae Gyu Park; Ji Hwan Kim; Ki Sung Kang
Journal:  Oncol Lett       Date:  2019-01-14       Impact factor: 2.967

2.  Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity.

Authors:  Ainieng Woo; Byungsun Min; Sungwoo Ryoo
Journal:  Exp Mol Med       Date:  2010-07-31       Impact factor: 8.718

Review 3.  Journey of anthraquinones as anticancer agents - a systematic review of recent literature.

Authors:  M Shaheer Malik; Reem I Alsantali; Rabab S Jassas; Abdulrahman A Alsimaree; Riyaz Syed; Meshari A Alsharif; Kulkarni Kalpana; Moataz Morad; Ismail I Althagafi; Saleh A Ahmed
Journal:  RSC Adv       Date:  2021-11-05       Impact factor: 4.036

Review 4.  A Review on Rhubarb-Derived Substances as Modulators of Cardiovascular Risk Factors-A Special Emphasis on Anti-Obesity Action.

Authors:  Oleksandra Liudvytska; Joanna Kolodziejczyk-Czepas
Journal:  Nutrients       Date:  2022-05-13       Impact factor: 6.706

5.  Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice.

Authors:  Minh Cong Nguyen; Sungwoo Ryoo
Journal:  Korean J Physiol Pharmacol       Date:  2016-12-21       Impact factor: 2.016

6.  Characterization and Comparative Analysis of Two Rheum Complete Chloroplast Genomes.

Authors:  Kaihui Zhao; Lianqiang Li; Yazhou Lu; Junbo Yang; Zhirong Zhang; Fangyu Zhao; Hong Quan; Xiaojing Ma; Zhihua Liao; Xiaozhong Lan
Journal:  Biomed Res Int       Date:  2020-06-19       Impact factor: 3.411

Review 7.  Chrysophanol: A Natural Anthraquinone with Multifaceted Biotherapeutic Potential.

Authors:  Mohd Aslam Yusuf; Brahma N Singh; Surya Sudheer; Ravindra N Kharwar; Saba Siddiqui; Ahmed M Abdel-Azeem; Leonardo Fernandes Fraceto; Kavya Dashora; Vijai K Gupta
Journal:  Biomolecules       Date:  2019-02-18

8.  Chrysophanol, Physcion, Hesperidin and Curcumin Modulate the Gene Expression of Pro-Inflammatory Mediators Induced by LPS in HepG2: In Silico and Molecular Studies.

Authors:  Nabil Mohamed Selim; Abdullah Abdurrahman Elgazar; Nabil Mohie Abdel-Hamid; Mohammed Rizk Abu El-Magd; Aziz Yasri; Hala Mohamed El Hefnawy; Mansour Sobeh
Journal:  Antioxidants (Basel)       Date:  2019-09-03

9.  Microbial Biosynthesis of Chrysazin Derivatives in Recombinant Escherichia coli and Their Biological Activities.

Authors:  Purna Bahadur Poudel; Dipesh Dhakal; Rubin Thapa Magar; Jae Kyung Sohng
Journal:  Molecules       Date:  2022-08-29       Impact factor: 4.927

10.  Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1 expression in macrophages and inflammatory lung injury.

Authors:  Ran Joo Choi; Mao-Sheng Cheng; Yeong Shik Kim
Journal:  Redox Biol       Date:  2014-02-18       Impact factor: 11.799
  10 in total

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