Literature DB >> 1621095

Fatty acid biosynthesis redirected to medium chains in transgenic oilseed plants.

T A Voelker1, A C Worrell, L Anderson, J Bleibaum, C Fan, D J Hawkins, S E Radke, H M Davies.   

Abstract

Medium-chain fatty acids (FAs), found in storage lipids of certain plants, are an important renewable resource. Seeds of undomesticated California bay accumulate laurate (12:0), and a 12:0-acyl-carrier protein thioesterase (BTE) has been purified from this tissue. Sequencing of BTE enabled the cloning of a complementary DNA coding for a plastid-targeted preprotein. Expression of the complementary DNA in the seeds of Arabidopsis thaliana resulted in BTE activity, and medium chains accumulated at the expense of long-chain (greater than or equal to 16) FAs. Laurate became the most abundant FA species and was deposited in the storage triacylglycerols. These results demonstrate a mechanism for medium-chain FA synthesis in plants.

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Year:  1992        PMID： 1621095     DOI： 10.1126/science.1621095

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  71 in total

Review 1.  Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering.

Authors:  Joris Beld; D John Lee; Michael D Burkart
Journal:  Mol Biosyst       Date:  2014-10-31

2.  T-DNA tagging in Brassica napus as an efficient tool for the isolation of new promoters for selectable marker genes.

Authors:  Jacob Bade; Emiel van Grinsven; Jerome Custers; Sietske Hoekstra; Anne Ponstein
Journal:  Plant Mol Biol       Date:  2003-05       Impact factor: 4.076

3.  Storage reserve accumulation in Arabidopsis: metabolic and developmental control of seed filling.

Authors:  Sébastien Baud; Bertrand Dubreucq; Martine Miquel; Christine Rochat; Loïc Lepiniec
Journal:  Arabidopsis Book       Date:  2008-07-24

4.  Acyl-Trafficking During Plant Oil Accumulation.

Authors:  Guanqun Chen; Helen K Woodfield; Xue Pan; John L Harwood; Randall J Weselake
Journal:  Lipids       Date:  2015-10-12       Impact factor: 1.880

5.  Effect of a mutagenized acyl-ACP thioesterase FATA allele from sunflower with improved activity in tobacco leaves and Arabidopsis seeds.

Authors:  Antonio Javier Moreno-Pérez; Mónica Venegas-Calerón; Fabián E Vaistij; Joaquin J Salas; Tony R Larson; Rafael Garcés; Ian A Graham; Enrique Martínez-Force
Journal:  Planta       Date:  2013-12-11       Impact factor: 4.116

6.  Isolation and characterization of two safflower oleoyl-acyl carrier protein thioesterase cDNA clones.

Authors:  D S Knutzon; J L Bleibaum; J Nelsen; J C Kridl; G A Thompson
Journal:  Plant Physiol       Date:  1992-12       Impact factor: 8.340

7.  Alteration of the specificity and regulation of fatty acid synthesis of Escherichia coli by expression of a plant medium-chain acyl-acyl carrier protein thioesterase.

Authors:  T A Voelker; H M Davies
Journal:  J Bacteriol       Date:  1994-12       Impact factor: 3.490

8.  A truncated FatB resulting from a single nucleotide insertion is responsible for reducing saturated fatty acids in maize seed oil.

Authors:  Peizhong Zheng; M D Ali Babar; Seshasai Parthasarathy; Ryan Gibson; Kelly Parliament; Josh Flook; Thomas Patterson; Peter Friedemann; Siva Kumpatla; Steve Thompson
Journal:  Theor Appl Genet       Date:  2014-05-07       Impact factor: 5.699

9.  Modification of the substrate specificity of an acyl-acyl carrier protein thioesterase by protein engineering.

Authors:  L Yuan; T A Voelker; D J Hawkins
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

10.  Acyl-lipid thioesterase1-4 from Arabidopsis thaliana form a novel family of fatty acyl-acyl carrier protein thioesterases with divergent expression patterns and substrate specificities.

Authors:  Ian P Pulsifer; Christine Lowe; Swara A Narayaran; Alia S Busuttil; Sollapura J Vishwanath; Frédéric Domergue; Owen Rowland
Journal:  Plant Mol Biol       Date:  2013-11-10       Impact factor: 4.076
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