RATIONALE: Sleep apnea is believed to be a genetic disorder. Thus, we hypothesized that anatomic risk factors for sleep apnea would demonstrate family aggregation. OBJECTIVES: We used volumetric magnetic resonance imaging in a sib pair "quad" design to study the family aggregation of the size of upper airway soft tissue structures that are associated with increased risk for obstructive sleep apnea. METHODS: We examined 55 sleep apnea probands (apnea-hypopnea index [AHI]: 43.2 +/- 26.3 events/h), 55 proband siblings (AHI: 11.8 +/- 16.6 events/h), 55 control subjects (AHI: 2.1 +/- 1.7 events/h), and 55 control siblings (AHI: 4.2 +/- 4.0 events/h). The study design used exact matching on ethnicity and sex, frequency matching on age, and statistical control for visceral neck fat and craniofacial dimensions. MEASUREMENTS AND MAIN RESULTS: The data support our a priori hypothesis that the volume of the important upper airway soft tissue structures is heritable. The volume of the lateral pharyngeal walls (h(2) = 36.8%; p = 0.001), tongue (h(2) = 36.5%; p = 0.0001), and total soft tissue (h(2) = 37.5%; p = 0.0001) demonstrated significant levels of heritability after adjusting for sex, ethnicity, age, visceral neck fat, and craniofacial dimensions. In addition, our data indicate that heritability of the upper airway soft tissue structures is found in normal subjects and patients with apnea. Thus, it is not simply a consequence of the prevalence of apnea. CONCLUSIONS: This is the first time family aggregation of size of the upper airway soft tissue structures has been demonstrated.
RATIONALE: Sleep apnea is believed to be a genetic disorder. Thus, we hypothesized that anatomic risk factors for sleep apnea would demonstrate family aggregation. OBJECTIVES: We used volumetric magnetic resonance imaging in a sib pair "quad" design to study the family aggregation of the size of upper airway soft tissue structures that are associated with increased risk for obstructive sleep apnea. METHODS: We examined 55 sleep apnea probands (apnea-hypopnea index [AHI]: 43.2 +/- 26.3 events/h), 55 proband siblings (AHI: 11.8 +/- 16.6 events/h), 55 control subjects (AHI: 2.1 +/- 1.7 events/h), and 55 control siblings (AHI: 4.2 +/- 4.0 events/h). The study design used exact matching on ethnicity and sex, frequency matching on age, and statistical control for visceral neck fat and craniofacial dimensions. MEASUREMENTS AND MAIN RESULTS: The data support our a priori hypothesis that the volume of the important upper airway soft tissue structures is heritable. The volume of the lateral pharyngeal walls (h(2) = 36.8%; p = 0.001), tongue (h(2) = 36.5%; p = 0.0001), and total soft tissue (h(2) = 37.5%; p = 0.0001) demonstrated significant levels of heritability after adjusting for sex, ethnicity, age, visceral neck fat, and craniofacial dimensions. In addition, our data indicate that heritability of the upper airway soft tissue structures is found in normal subjects and patients with apnea. Thus, it is not simply a consequence of the prevalence of apnea. CONCLUSIONS: This is the first time family aggregation of size of the upper airway soft tissue structures has been demonstrated.
Authors: Lyle J Palmer; Sarah G Buxbaum; Emma K Larkin; Sanjay R Patel; Robert C Elston; Peter V Tishler; Susan Redline Journal: Am J Respir Crit Care Med Date: 2004-04-07 Impact factor: 21.405
Authors: Lane F Donnelly; Sally R Shott; Connor R LaRose; Barbara A Chini; Raouf S Amin Journal: AJR Am J Roentgenol Date: 2004-07 Impact factor: 3.959
Authors: S Redline; P V Tishler; T D Tosteson; J Williamson; K Kump; I Browner; V Ferrette; P Krejci Journal: Am J Respir Crit Care Med Date: 1995-03 Impact factor: 21.405
Authors: Danielle Andrade da Silva Dantas; Thais Mauad; Luiz F F Silva; Geraldo Lorenzi-Filho; Gilberto G S Formigoni; Michel B Cahali Journal: Sleep Date: 2012-04-01 Impact factor: 5.849
Authors: Steven D Shapiro; Chien-Hung Chin; Jason P Kirkness; Brian M McGinley; Susheel P Patil; Vsevolod Y Polotsky; Paolo Jose Cesare Biselli; Philip L Smith; Hartmut Schneider; Alan R Schwartz Journal: J Appl Physiol (1985) Date: 2014-02-20
Authors: Michael J Brennick; Allan I Pack; Kei Ko; Eugene Kim; Stephen Pickup; Greg Maislin; Richard J Schwab Journal: Am J Respir Crit Care Med Date: 2008-11-07 Impact factor: 21.405