BACKGROUND AND PURPOSE: A relationship between the apolipoprotein E (apoE) genotype and ischemic stroke has been inconsistently reported. We explored this relation in the Atherosclerosis Risk in Communities Study (ARIC). METHODS: The ARIC cohort involves 15 792 men and women, aged 45 to 64 years at baseline and sampled from 4 U.S. communities. Between 1987 and 2001, 498 incident ischemic strokes occurred. RESULTS: After stratifying by race and sex and adjusting for other nonlipid risk factors, there was no significant relation between the apoE genotype and incident stroke, except in black women (hazard ratio for epsilon2 genotype relative to epsilon3/epsilon3=0.53; 95% CI, 0.28 to 0.99). CONCLUSIONS: For the most part, in this middle-aged sample, apoE was not a risk factor for incident ischemic stroke.
BACKGROUND AND PURPOSE: A relationship between the apolipoprotein E (apoE) genotype and ischemic stroke has been inconsistently reported. We explored this relation in the Atherosclerosis Risk in Communities Study (ARIC). METHODS: The ARIC cohort involves 15 792 men and women, aged 45 to 64 years at baseline and sampled from 4 U.S. communities. Between 1987 and 2001, 498 incident ischemic strokes occurred. RESULTS: After stratifying by race and sex and adjusting for other nonlipid risk factors, there was no significant relation between the apoE genotype and incident stroke, except in black women (hazard ratio for epsilon2 genotype relative to epsilon3/epsilon3=0.53; 95% CI, 0.28 to 0.99). CONCLUSIONS: For the most part, in this middle-aged sample, apoE was not a risk factor for incident ischemic stroke.
Authors: Ni Putu Tesi Maratni; Made Ratna Saraswati; Ni Nyoman Ayu Dewi; I Wayan Putu Sutirta Yasa; I Putu Eka Widyadharma; Ida Bagus Kusuma Putra; Ketut Suastika Journal: J Nutr Metab Date: 2021-03-26
Authors: Anitha Pitchika; Marcello Ricardo Paulista Markus; Sabine Schipf; Alexander Teumer; Sandra Van der Auwera; Matthias Nauck; Marcus Dörr; Stephan Felix; Hans-Jörgen Grabe; Henry Völzke; Till Ittermann Journal: Sci Rep Date: 2022-03-24 Impact factor: 4.379