Literature DB >> 16210527

Transforming growth factor-beta signaling in stem cells and cancer.

Lopa Mishra1, Rik Derynck, Bibhuti Mishra.   

Abstract

Transforming growth factor-beta (TGF-beta) and TGF-beta-related proteins, such as the bone morphogenetic proteins, have emerged as key regulators of stem cell renewal and differentiation. These proteins have disparate roles in regulating the biology of embryonic stem cells and tumor suppression, and they help define the selection of cell fate and the progression of differentiation along a lineage. Here we illustrate their roles in embryonic stem cells and in the differentiation of neural, hematopoietic, mesenchymal, and gastrointestinal epithelial stem cells.

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Year:  2005        PMID： 16210527     DOI： 10.1126/science.1118389

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  97 in total

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Review 9.  Cancer stem cells and hepatocellular carcinoma.

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