Literature DB >> 16210494

Critical investigation of the CD14 promoter polymorphism: lack of a role for in vitro cytokine response and membrane CD14 expression.

Sonja von Aulock1, Jan Rupp, Katja Gueinzius, Matthias Maass, Corinna Hermann.   

Abstract

Blood of volunteers, genotyped for the CD14 C(-159)-->T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.

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Year:  2005        PMID： 16210494      PMCID： PMC1247820          DOI： 10.1128/CDLI.12.10.1254-1256.2005

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  16 in total

1.  Polymorphism in the promoter of lipopolysaccharide receptor CD14 and ischemic cerebrovascular disease.

Authors:  D Ito; M Murata; N Tanahashi; H Sato; A Sonoda; I Saito; K Watanabe; Y Fukuuchi
Journal:  Stroke       Date:  2000-11       Impact factor: 7.914

2.  A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity.

Authors:  T D LeVan; J W Bloom; T J Bailey; C L Karp; M Halonen; F D Martinez; D Vercelli
Journal:  J Immunol       Date:  2001-11-15       Impact factor: 5.422

3.  A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E.

Authors:  M Baldini; I C Lohman; M Halonen; R P Erickson; P G Holt; F D Martinez
Journal:  Am J Respir Cell Mol Biol       Date:  1999-05       Impact factor: 6.914

4.  CD14 gene -159C/T polymorphism is not associated with coronary artery disease and myocardial infarction.

Authors:  Werner Koch; Adnan Kastrati; Julinda Mehilli; Nicolas von Beckerath; Albert Schömig
Journal:  Am Heart J       Date:  2002-06       Impact factor: 4.749

5.  CD14 promoter polymorphism is associated with acute myocardial infarction resulting from insignificant coronary artery stenosis.

Authors:  T Kondo; M Ohno; K Shimokata; S Iino; Y Inden; T Murohara; M Hirai
Journal:  Heart       Date:  2003-08       Impact factor: 5.994

6.  Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood.

Authors:  Sonja von Aulock; Nicolas W J Schröder; Katja Gueinzius; Stephanie Traub; Sebastian Hoffmann; Kathrin Graf; Stefanie Dimmeler; Thomas Hartung; Ralf R Schumann; Corinna Hermann
Journal:  J Infect Dis       Date:  2003-08-28       Impact factor: 5.226

7.  Lack of association between the -260 C-->T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels.

Authors:  M Heesen; B Blömeke; B Schlüter; N Heussen; R Rossaint; D Kunz
Journal:  Intensive Care Med       Date:  2001-10-30       Impact factor: 17.440

8.  A prospective evaluation of the CD14 C(-260)T gene polymorphism and the risk of myocardial infarction.

Authors:  R Y Zee; K Lindpaintner; B Struk; C H Hennekens; P M Ridker
Journal:  Atherosclerosis       Date:  2001-02-15       Impact factor: 5.162

9.  A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile.

Authors:  K Unkelbach; A Gardemann; M Kostrzewa; M Philipp; H Tillmanns; W Haberbosch
Journal:  Arterioscler Thromb Vasc Biol       Date:  1999-04       Impact factor: 8.311

10.  TLR4/Asp299Gly, CD14/C-260T, plasma levels of the soluble receptor CD14 and the risk of coronary heart disease: The PRIME Study.

Authors:  P E Morange; L Tiret; N Saut; G Luc; D Arveiler; J Ferrieres; P Amouyel; A Evans; P Ducimetiere; F Cambien; I Juhan-Vague
Journal:  Eur J Hum Genet       Date:  2004-12       Impact factor: 4.246
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  2 in total

1.  CD14-159C/T polymorphism in the development of delayed skin hypersensitivity to tuberculin.

Authors:  Magdalena Druszczynska; Marcin Wlodarczyk; Grzegorz Kielnierowski; Michal Seweryn; Sebastian Wawrocki; Wieslawa Rudnicka
Journal:  PLoS One       Date:  2017-12-27       Impact factor: 3.240

Review 2.  Bench-to-bedside review: Association of genetic variation with sepsis.

Authors:  Ainsley M Sutherland; Keith R Walley
Journal:  Crit Care       Date:  2009-04-29       Impact factor: 9.097
  2 in total

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