Literature DB >> 16209593

A novel route to fully substituted 1H-pyrazoles.

Yat Fan Suen1, Håkon Hope, Michael H Nantz, Makhluf J Haddadin, Mark J Kurth.   

Abstract

A novel one-step synthesis route to fully substituted pyrazol-4-ols is reported. This simple yet nonobvious method for the construction of pyrazol-4-ols by the condensation-fragmentation-cyclization-extrusion reactions of thietanones with 1,2,4,5-tetrazines is reported. All of the elements of the thietanone except its sulfur are incorporated in these novel products.

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Year:  2005        PMID: 16209593     DOI: 10.1021/jo051319a

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

Review 1.  Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Authors:  Khalid Karrouchi; Smaail Radi; Youssef Ramli; Jamal Taoufik; Yahia N Mabkhot; Faiz A Al-Aizari; M'hammed Ansar
Journal:  Molecules       Date:  2018-01-12       Impact factor: 4.411

2.  Transannular Anti-Michael Addition: Formation of 4H-Pyrazolo[5,1-c]thiazines.

Authors:  Yat Fan Suen; Håkon Hope; Michael H Nantz; Makhluf J Haddadin; And Mark J Kurth
Journal:  Tetrahedron Lett       Date:  2006-11-06       Impact factor: 2.415

  2 in total

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