Literature DB >> 16209486

Synthesis of the C7-C15 trans decalin portion of the natural antibiotic tetrodecamycin.

Jeffrey M Warrington1, Louis Barriault.   

Abstract

[reaction: see text] The tandem oxy-Cope/ene/Claisen rearrangement has been developed in our laboratory as a powerful method for rapid construction of complex Decalin cores. Herein, we describe the use of this method to generate the Decalin core of the natural antibiotic tetrodecamycin (1) bearing six contiguous stereocenters.

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Year:  2005        PMID: 16209486     DOI: 10.1021/ol051715f

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

Review 1.  Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development.

Authors:  Wanli Zhang; Anna R Kaplan; Emma K Davison; Jared L Freeman; Margaret A Brimble; William M Wuest
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 13.423

  1 in total

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