Literature DB >> 16207995

Mycobacterium avium subsp. paratuberculosis, genetic susceptibility to Crohn's disease, and Sardinians: the way ahead.

Leonardo A Sechi1, Maria Gazouli, John Ikonomopoulos, John C Lukas, Antonio M Scanu, Niyaz Ahmed, Giovanni Fadda, Stefania Zanetti.   

Abstract

The present study was performed to determine what proportion of people in Sardinia with or without Crohn's disease were infected with Mycobacterium avium subspecies paratuberculosis and had a preponderance of allelic variants of Nod 2, an intracellular protein involved in Crohn's disease susceptibility. Genetic analysis of the alleles of the NOD 2/CARD 15 gene (ins C 3020, G 908 R, and R 702 W alleles), linked to susceptibility or genetic predisposition to Crohn's disease in humans, was carried out on specimens from 37 Crohn's disease patients and 34 patients without Crohn's disease. Our results show that more than 70 percent of people in Sardinia with Crohn's disease carry at least one of the susceptibility-associated NOD 2/CARD 15 alleles and were infected with Mycobacterium avium subspecies paratuberculosis.

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Year:  2005        PMID： 16207995      PMCID： PMC1248481          DOI： 10.1128/JCM.43.10.5275-5277.2005

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  12 in total

1.  Identification of Mycobacterium avium subsp. paratuberculosis in biopsy specimens from patients with Crohn's disease identified by in situ hybridization.

Authors:  L A Sechi; M Mura; F Tanda; A Lissia; A Solinas; G Fadda; S Zanetti; M Manuela; T Francesco; L Amelia; S Antonello; F Giovanni; Z Stefania
Journal:  J Clin Microbiol       Date:  2001-12       Impact factor: 5.948

Review 2.  Inflammatory bowel disease.

Authors:  Daniel K Podolsky
Journal:  N Engl J Med       Date:  2002-08-08       Impact factor: 91.245

3.  Crohn's disease, mycobacteria, and NOD2.

Authors:  Marcel A Behr; Makeda Semret; Audrey Poon; Erwin Schurr
Journal:  Lancet Infect Dis       Date:  2004-03       Impact factor: 25.071

4.  Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.

Authors:  J P Hugot; M Chamaillard; H Zouali; S Lesage; J P Cézard; J Belaiche; S Almer; C Tysk; C A O'Morain; M Gassull; V Binder; Y Finkel; A Cortot; R Modigliani; P Laurent-Puig; C Gower-Rousseau; J Macry; J F Colombel; M Sahbatou; G Thomas
Journal:  Nature       Date:  2001-05-31       Impact factor: 49.962

5.  A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.

Authors:  Y Ogura; D K Bonen; N Inohara; D L Nicolae; F F Chen; R Ramos; H Britton; T Moran; R Karaliuskas; R H Duerr; J P Achkar; S R Brant; T M Bayless; B S Kirschner; S B Hanauer; G Nuñez; J H Cho
Journal:  Nature       Date:  2001-05-31       Impact factor: 49.962

6.  Detection and Isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn's disease in Sardinia.

Authors:  Leonardo A Sechi; Antonio M Scanu; Paola Molicotti; Sara Cannas; Manuela Mura; Giuseppe Dettori; Giovanni Fadda; Stefania Zanetti
Journal:  Am J Gastroenterol       Date:  2005-07       Impact factor: 10.864

7.  Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease.

Authors:  Saleh A Naser; George Ghobrial; Claudia Romero; John F Valentine
Journal:  Lancet       Date:  2004 Sep 18-24       Impact factor: 79.321

8.  Lack of common NOD2 variants in Japanese patients with Crohn's disease.

Authors:  Nagamu Inoue; Kazuo Tamura; Yoshitaka Kinouchi; Yoshihiro Fukuda; Seiichi Takahashi; Yasunori Ogura; Naohiro Inohara; Gabriel Núñez; Yusuke Kishi; Yuji Koike; Tooru Shimosegawa; Takashi Shimoyama; Toshifumi Hibi
Journal:  Gastroenterology       Date:  2002-07       Impact factor: 22.682

9.  Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.

Authors:  Naohiro Inohara; Yasunori Ogura; Ana Fontalba; Olga Gutierrez; Fernando Pons; Javier Crespo; Koichi Fukase; Seiichi Inamura; Shoichi Kusumoto; Masahito Hashimoto; Simon J Foster; Anthony P Moran; Jose L Fernandez-Luna; Gabriel Nuñez
Journal:  J Biol Chem       Date:  2003-01-04       Impact factor: 5.157

10.  Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations.

Authors:  J Hampe; A Cuthbert; P J Croucher; M M Mirza; S Mascheretti; S Fisher; H Frenzel; K King; A Hasselmeyer; A J MacPherson; S Bridger; S van Deventer; A Forbes; S Nikolaus; J E Lennard-Jones; U R Foelsch; M Krawczak; C Lewis; S Schreiber; C G Mathew
Journal:  Lancet       Date:  2001-06-16       Impact factor: 79.321
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  18 in total

Review 1.  Mycobacterium avium paratuberculosis and the etiology of Crohn's disease: a review of the controversy from the clinician's perspective.

Authors:  Greg Rosenfeld; Brian Bressler
Journal:  Can J Gastroenterol       Date:  2010-10       Impact factor: 3.522

2.  Testing the interaction between NOD-2 status and serological response to Mycobacterium paratuberculosis in cases of inflammatory bowel disease.

Authors:  Charles N Bernstein; Ming-Hsi Wang; Michael Sargent; Steven R Brant; Michael T Collins
Journal:  J Clin Microbiol       Date:  2007-01-24       Impact factor: 5.948

3.  Mapping the effects of genetic susceptibility and Mycobacterium avium subsp. paratuberculosis infection on Crohn's disease: strong but independent.

Authors:  Lee E Sieswerda; Robert M Bannatyne
Journal:  J Clin Microbiol       Date:  2006-03       Impact factor: 5.948

Review 4.  Microbial host interactions in IBD: implications for pathogenesis and therapy.

Authors:  R Balfour Sartor; Marcus Muehlbauer
Journal:  Curr Gastroenterol Rep       Date:  2007-12

5.  Comparative transcriptional analysis of human macrophages exposed to animal and human isolates of Mycobacterium avium subspecies paratuberculosis with diverse genotypes.

Authors:  Alifiya S Motiwala; Harish K Janagama; Michael L Paustian; Xiaochun Zhu; John P Bannantine; Vivek Kapur; Srinand Sreevatsan
Journal:  Infect Immun       Date:  2006-11       Impact factor: 3.441

6.  Intestinal microbiota in inflammatory bowel disease: friend of foe?

Authors:  Francesca Fava; Silvio Danese
Journal:  World J Gastroenterol       Date:  2011-02-07       Impact factor: 5.742

7.  Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients.

Authors:  Leonardo-A Sechi; Maria Gazouli; Lee-E Sieswerda; Paola Molicotti; Niyaz Ahmed; John Ikonomopoulos; Antonio-M Scanu; Daniela Paccagnini; Stefania Zanetti
Journal:  World J Gastroenterol       Date:  2006-11-28       Impact factor: 5.742

Review 8.  On deaf ears, Mycobacterium avium paratuberculosis in pathogenesis Crohn's and other diseases.

Authors:  William C Davis
Journal:  World J Gastroenterol       Date:  2015-12-28       Impact factor: 5.742

9.  Possible transmission of Mycobacterium avium subspecies paratuberculosis through potable water: lessons from an urban cluster of Crohn's disease.

Authors:  Ellen S Pierce
Journal:  Gut Pathog       Date:  2009-09-23       Impact factor: 4.181

10.  Specific immunoassays confirm association of Mycobacterium avium Subsp. paratuberculosis with type-1 but not type-2 diabetes mellitus.

Authors:  Valentina Rosu; Niyaz Ahmed; Daniela Paccagnini; Gerald Gerlach; Giovanni Fadda; Seyed E Hasnain; Stefania Zanetti; Leonardo A Sechi
Journal:  PLoS One       Date:  2009-02-10       Impact factor: 3.240
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