Literature DB >> 16207502

Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease.

Omanma Adighibe1, Sampath Arepalli, Jaime Duckworth, John Hardy, Fabienne Wavrant-De Vrièze.   

Abstract

We have initiated a systematic analysis of the role of cholesterol metabolizing genes as risk factors for Alzheimer's disease pathogenesis. As part of this analysis, we have assessed the NR1H2 gene on chromosome 19 and report here a modest association with the locus in sibpairs with late onset disease.

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Year:  2005        PMID： 16207502     DOI： 10.1016/j.neurobiolaging.2005.08.010

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  13 in total

Review 1.  Sterol regulation of metabolism, homeostasis, and development.

Authors:  Joshua Wollam; Adam Antebi
Journal:  Annu Rev Biochem       Date:  2011       Impact factor: 23.643

Review 2.  LXR agonists: new potential therapeutic drug for neurodegenerative diseases.

Authors:  Pei Xu; Dabing Li; Xiaotong Tang; Xiaohang Bao; Jing Huang; Yongping Tang; Yang Yang; Haiwei Xu; Xiaotang Fan
Journal:  Mol Neurobiol       Date:  2013-04-27       Impact factor: 5.590

3.  Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease.

Authors:  Vibeke Andersen; Jane Christensen; Anja Ernst; Bent A Jacobsen; Anne Tjønneland; Henrik B Krarup; Ulla Vogel
Journal:  World J Gastroenterol       Date:  2011-01-14       Impact factor: 5.742

4.  Liver X Receptor: Crosstalk Node for the Signaling of Lipid Metabolism, Carbohydrate Metabolism, and Innate Immunity.

Authors:  Michael B Fessler
Journal:  Curr Signal Transduct Ther       Date:  2008-05-01

Review 5.  Minireview: liver X receptor beta: emerging roles in physiology and diseases.

Authors:  Chiara Gabbi; Margaret Warner; Jan-Ake Gustafsson
Journal:  Mol Endocrinol       Date:  2008-12-12

Review 6.  PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease.

Authors:  Gary Landreth; Qingguang Jiang; Shweta Mandrekar; Michael Heneka
Journal:  Neurotherapeutics       Date:  2008-07       Impact factor: 7.620

Review 7.  The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications.

Authors:  Qingguang Jiang; Michael Heneka; Gary E Landreth
Journal:  CNS Drugs       Date:  2008       Impact factor: 5.749

Review 8.  Liver X receptors: from cholesterol regulation to neuroprotection-a new barrier against neurodegeneration in amyotrophic lateral sclerosis?

Authors:  Kevin Mouzat; Cédric Raoul; Anne Polge; Jovana Kantar; William Camu; Serge Lumbroso
Journal:  Cell Mol Life Sci       Date:  2016-08-10       Impact factor: 9.261

9.  Association study of cholesterol-related genes in Alzheimer's disease.

Authors:  M Axel Wollmer; Kristel Sleegers; Martin Ingelsson; Cezary Zekanowski; Nathalie Brouwers; Aleksandra Maruszak; Fabienne Brunner; Kim-Dung Huynh; Lena Kilander; Rose-Marie Brundin; Marie Hedlund; Vilmantas Giedraitis; Anna Glaser; Sebastiaan Engelborghs; Peter P De Deyn; Elisabeth Kapaki; Magdalini Tsolaki; Makrina Daniilidou; Dimitra Molyva; George P Paraskevas; Dietmar R Thal; Maria Barcikowska; Jacek Kuznicki; Lars Lannfelt; Christine Van Broeckhoven; Roger M Nitsch; Christoph Hock; Andreas Papassotiropoulos
Journal:  Neurogenetics       Date:  2007-03-27       Impact factor: 3.017

10.  Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans.

Authors:  Ja-Young Jeon; Jin-Young Nam; Hyoun-Ah Kim; Yong-Beom Park; Sang-Cheol Bae; Chang-Hee Suh
Journal:  Arthritis Res Ther       Date:  2014-05-14       Impact factor: 5.156
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