OBJECTIVE: To evaluate the effect of nano-hydroxyapatite collagen (nHAC) bone and marrow mesenchymal stem cells (MSCs) on the treatment of rabbit osteonecrosis of the femoral head (ONFH) defect. METHODS: From June to October 2004, animal models of ONFH defect were established in 45 New Zealand rabbits. They were divided into 3 groups randomly: In group A, as the control group, defect was not filled with any implants; In group B with nHAC; In group C with nHAC+MSC. Imaging and histological observation were made 4, 8, 12 weeks after operation. RESULTS: group C had a better osteogenesis ability than group B and group A. group B had a better osteogenesis ability than group A. Obvious new bones and osteogenesis were observed in group C 4 weeks after operation. The defect areas in group C were almost repaired 12 weeks after operation. CONCLUSION: nHAC has a better effect of osteo-conduction and it is a superior material for repairing bone defect of ONFH and of great value in treating ONFH when compounded with MSCs.
OBJECTIVE: To evaluate the effect of nano-hydroxyapatite collagen (nHAC) bone and marrow mesenchymal stem cells (MSCs) on the treatment of rabbit osteonecrosis of the femoral head (ONFH) defect. METHODS: From June to October 2004, animal models of ONFH defect were established in 45 New Zealand rabbits. They were divided into 3 groups randomly: In group A, as the control group, defect was not filled with any implants; In group B with nHAC; In group C with nHAC+MSC. Imaging and histological observation were made 4, 8, 12 weeks after operation. RESULTS: group C had a better osteogenesis ability than group B and group A. group B had a better osteogenesis ability than group A. Obvious new bones and osteogenesis were observed in group C 4 weeks after operation. The defect areas in group C were almost repaired 12 weeks after operation. CONCLUSION: nHAC has a better effect of osteo-conduction and it is a superior material for repairing bone defect of ONFH and of great value in treating ONFH when compounded with MSCs.