Literature DB >> 16205834

Systematic classification of alleles of the glycophorin A (MN blood group) gene.

Hajime Mizukami1, Atsushi Akane, Nori Nakayashiki, Yasuhiro Aoki, Hiroshi Shiono.   

Abstract

Ten alleles (five M and five N alleles) of the MN blood group system with normal antigenicity were found by sequencing the glycophorin A (GPA) gene. This study demonstrates the systematic classification of these alleles to major or minor variations of the standard alleles. GPA-specific fragments ranging from 150 to 3.8 kb in length were amplified from the templates, and exons 1-7 and introns 1-6 were sequenced. The data were analyzed phylogenetically to classify these alleles into major groups or clusters. The ten alleles were grouped into four major clusters M10X (M101-M103), M20X (M201 and M202), N10X (N101-N104) and N20X (N201), where 'X' represents a digit indicating minor variations. This grouping was supported by phylogenetic analysis. The cluster system of GPA alleles is highly informative for genetic screening.

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Year:  2005        PMID： 16205834     DOI： 10.1007/s10038-005-0306-0

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  13 in total

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Authors:  J R Storry; J Poole; J Condon; M E Reid
Journal:  Transfusion       Date:  2000-05       Impact factor: 3.157

2.  Allele-specific, inverse-PCR amplification for genotyping MN blood group.

Authors:  Z X Li; S Yoshimura; T Kobayashi; A Akane
Journal:  Biotechniques       Date:  1998-09       Impact factor: 1.993

3.  PCR-based genotyping of MNSs blood group: subtyping of M allele to MG and MT.

Authors:  A Akane; T Kobayashi; Z X Li; S Yoshimura; Y Okii; M Yoshida; T Tokiyasu; T Watabiki
Journal:  Jpn J Hum Genet       Date:  1997-12

4.  Evolution of primate ABO blood group genes and their homologous genes.

Authors:  N Saitou; F Yamamoto
Journal:  Mol Biol Evol       Date:  1997-04       Impact factor: 16.240

5.  Guidelines for human gene nomenclature. An international system for human gene nomenclature (ISGN, 1987).

Authors:  T B Shows; P J McAlpine; C Boucheix; F S Collins; P M Conneally; J Frézal; H Gershowitz; P N Goodfellow; J G Hall; P Issitt; C A Jones; B B Knowles; M Lewis; V A McKusick; M Meisler; N E Morton; P Rubenstein; M S Schanfield; R D Schmickel; M H Skolnick; M A Spence; G R Sutherland; M Traver; N Van Cong; H F Willard
Journal:  Cytogenet Cell Genet       Date:  1987

6.  Molecular analysis of a hybrid gene encoding human glycophorin variant Miltenberger V-like molecule.

Authors:  S Kudo; D Chagnovich; A Rearden; M G Mattei; M Fukuda
Journal:  J Biol Chem       Date:  1990-08-15       Impact factor: 5.157

7.  Classification of standard alleles of the MN blood group system.

Authors:  A Akane; H Mizukami; H Shiono
Journal:  Vox Sang       Date:  2000       Impact factor: 2.144

8.  An application of PCR-single strand conformation polymorphism to MN genotyping.

Authors:  Y Sasaki; N Nakayashiki; K Saigusa; M Takamiya; Y Aoki
Journal:  Leg Med (Tokyo)       Date:  2000-10       Impact factor: 1.376

9.  Molecular evolution of alleles of the glycophorin A gene.

Authors:  Hajime Mizukami; Atsushi Akane; Hiroshi Shiono; Kento Ogawa
Journal:  Leg Med (Tokyo)       Date:  2002-03       Impact factor: 1.376

10.  Molecular analysis of glycophorin A and B gene structure and expression in homozygous Miltenberger class V (Mi. V) human erythrocytes.

Authors:  A Vignal; C Rahuel; B el Maliki; J London; C le van Kim; D Blanchard; C Andre; L d'Auriol; F Galibert; M A Blajchman
Journal:  Eur J Biochem       Date:  1989-09-15
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