Literature DB >> 16205721

Plant cannabinoids: a neglected pharmacological treasure trove.

Raphael Mechoulam1.   

Abstract

Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents evidence that a plant cannabinoid, Delta(9)-tetrahydrocannabivarin is a potent antagonist of anandamide, a major endogenous cannabinoid. It seems possible that many of the non-psychoactive constituents of this plant will be of biological interest.

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Year:  2005        PMID： 16205721      PMCID： PMC1751232          DOI： 10.1038/sj.bjp.0706415

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.

Authors:  Adèle Thomas; Lesley A Stevenson; Kerrie N Wease; Martin R Price; Gemma Baillie; Ruth A Ross; Roger G Pertwee
Journal:  Br J Pharmacol       Date:  2005-12       Impact factor: 8.739

2.  Preliminary experiments on the chemistry and pharmacology of cannabis.

Authors:  E W Gill; W D Paton; R G Pertwee
Journal:  Nature       Date:  1970-10-10       Impact factor: 49.962

3.  (-)-Delta9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase.

Authors:  M Bayewitch; M H Rhee; T Avidor-Reiss; A Breuer; R Mechoulam; Z Vogel
Journal:  J Biol Chem       Date:  1996-04-26       Impact factor: 5.157

Review 4.  International Union of Pharmacology. XXVII. Classification of cannabinoid receptors.

Authors:  A C Howlett; F Barth; T I Bonner; G Cabral; P Casellas; W A Devane; C C Felder; M Herkenham; K Mackie; B R Martin; R Mechoulam; R G Pertwee
Journal:  Pharmacol Rev       Date:  2002-06       Impact factor: 25.468

5.  Biphasic effects of anandamide.

Authors:  E Sulcova; R Mechoulam; E Fride
Journal:  Pharmacol Biochem Behav       Date:  1998-02       Impact factor: 3.533

6.  Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery.

Authors:  W-S Vanessa Ho; C Robin Hiley
Journal:  Br J Pharmacol       Date:  2003-04       Impact factor: 8.739

7.  Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol.

Authors:  E Fride; J Barg; R Levy; D Saya; E Heldman; R Mechoulam; Z Vogel
Journal:  J Pharmacol Exp Ther       Date:  1995-02       Impact factor: 4.030
  7 in total
  38 in total

1.  Cannabinoid Inheritance Relies on Complex Genetic Architecture.

Authors:  Lesley G Campbell; Jaimie Dufresne; Sarah A Sabatinos
Journal:  Cannabis Cannabinoid Res       Date:  2020-02-27

Review 2.  Human cannabinoid pharmacokinetics.

Authors:  Marilyn A Huestis
Journal:  Chem Biodivers       Date:  2007-08       Impact factor: 2.408

3.  Associations between adolescent cannabis use and brain structure in psychosis.

Authors:  Hila Abush; Subroto Ghose; Erin A Van Enkevort; Brett A Clementz; Godfrey D Pearlson; John A Sweeney; Matcheri S Keshavan; Carol A Tamminga; Elena I Ivleva
Journal:  Psychiatry Res Neuroimaging       Date:  2018-03-28       Impact factor: 2.376

4.  Can oral fluid cannabinoid testing monitor medication compliance and/or cannabis smoking during oral THC and oromucosal Sativex administration?

Authors:  Dayong Lee; Erin L Karschner; Garry Milman; Allan J Barnes; Robert S Goodwin; Marilyn A Huestis
Journal:  Drug Alcohol Depend       Date:  2012-11-10       Impact factor: 4.492

5.  The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis.

Authors:  J M Jamontt; A Molleman; R G Pertwee; M E Parsons
Journal:  Br J Pharmacol       Date:  2010-06       Impact factor: 8.739

6.  Impact of Cannabis Use on the Development of Psychotic Disorders.

Authors:  Samuel T Wilkinson; Rajiv Radhakrishnan; Deepak Cyril D'Souza
Journal:  Curr Addict Rep       Date:  2014-06-01

7.  Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist.

Authors:  M G Cascio; L A Gauson; L A Stevenson; R A Ross; R G Pertwee
Journal:  Br J Pharmacol       Date:  2009-12-04       Impact factor: 8.739

Review 8.  The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.

Authors:  R G Pertwee
Journal:  Br J Pharmacol       Date:  2007-09-10       Impact factor: 8.739

Review 9.  An overview on the biochemistry of the cannabinoid system.

Authors:  María Gómez-Ruiz; Mariluz Hernández; Rosario de Miguel; Jose A Ramos
Journal:  Mol Neurobiol       Date:  2007-06-30       Impact factor: 5.590

10.  Identification of candidate genes affecting Delta9-tetrahydrocannabinol biosynthesis in Cannabis sativa.

Authors:  M David Marks; Li Tian; Jonathan P Wenger; Stephanie N Omburo; Wilfredo Soto-Fuentes; Ji He; David R Gang; George D Weiblen; Richard A Dixon
Journal:  J Exp Bot       Date:  2009-07-06       Impact factor: 6.992
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