OBJECTIVES: The objectives of this study were to determine the rate of new infections and reinfections or persistent infections with Chlamydia trachomatis to define appropriate screening intervals and to identify risk factors for reinfection. DESIGN: This was a cross-sectional study among a subsample of participants in a population-based screening. SETTING: This study was conducted in urban and rural areas in The Netherlands. PARTICIPANTS: A total of 21,000 15- to 29-year-old women and men were invited for home-based urine testing. One year after the study, a subsample of 299 participants were offered retesting. MAIN OUTCOME MEASURES: The authors studied the rate of infection with C. trachomatis. Serovar determination was used to potentially discriminate between new infections and reinfections or persistent infections. RESULTS: Nine C. trachomatis infections were found among 187 responders (4.8% confidence interval, 1.7-7.9). The prevalence was 10.4% (5 of 48) in previous positives and 2.9% (4 of 139) in negatives. Three of 5 repeatedly positive participants were infected with a different C. trachomatis serovar. CONCLUSIONS: Our study indicates that infected persons found in a systematic, population-based screening should be re-screened within 1 year. Optimal screening intervals still need to be determined.
OBJECTIVES: The objectives of this study were to determine the rate of new infections and reinfections or persistent infections with Chlamydia trachomatis to define appropriate screening intervals and to identify risk factors for reinfection. DESIGN: This was a cross-sectional study among a subsample of participants in a population-based screening. SETTING: This study was conducted in urban and rural areas in The Netherlands. PARTICIPANTS: A total of 21,000 15- to 29-year-old women and men were invited for home-based urine testing. One year after the study, a subsample of 299 participants were offered retesting. MAIN OUTCOME MEASURES: The authors studied the rate of infection with C. trachomatis. Serovar determination was used to potentially discriminate between new infections and reinfections or persistent infections. RESULTS: Nine C. trachomatis infections were found among 187 responders (4.8% confidence interval, 1.7-7.9). The prevalence was 10.4% (5 of 48) in previous positives and 2.9% (4 of 139) in negatives. Three of 5 repeatedly positive participants were infected with a different C. trachomatis serovar. CONCLUSIONS: Our study indicates that infected persons found in a systematic, population-based screening should be re-screened within 1 year. Optimal screening intervals still need to be determined.
Authors: Qing He; Luis Martinez-Sobrido; Francis O Eko; Peter Palese; Adolfo Garcia-Sastre; Deborah Lyn; Daniel Okenu; Claudiu Bandea; Godwin A Ananaba; Carolyn M Black; Joseph U Igietseme Journal: Immunology Date: 2007-04-23 Impact factor: 7.397
Authors: Jan E A M van Bergen; Johannes S A Fennema; Ingrid V F van den Broek; Elfi E H G Brouwers; Eva M de Feijter; Christian J P A Hoebe; Rik H Koekenbier; Eline L M Op de Coul; Sander M van Ravesteijn; Hannelore M Götz Journal: BMC Infect Dis Date: 2010-10-07 Impact factor: 3.090
Authors: Jennifer Walker; Sepehr N Tabrizi; Christopher K Fairley; Marcus Y Chen; Catriona S Bradshaw; Jimmy Twin; Nicole Taylor; Basil Donovan; John M Kaldor; Kathleen McNamee; Eve Urban; Sandra Walker; Marian Currie; Hudson Birden; Francis Bowden; Jane Gunn; Marie Pirotta; Lyle Gurrin; Veerakathy Harindra; Suzanne M Garland; Jane S Hocking Journal: PLoS One Date: 2012-05-25 Impact factor: 3.240
Authors: Karin Edgardh; Sharon Kühlmann-Berenzon; Maria Grünewald; Maria Rotzen-Ostlund; Ivar Qvarnström; Jennie Everljung Journal: BMC Public Health Date: 2009-06-22 Impact factor: 3.295