| Literature DB >> 16205004 |
Hiroshi Maruoka1, Nobuhiro Kashige, Fumio Miake, Tadatoshi Yamaguchi.
Abstract
Treatment of 1,2-cyclohexanedione with 1,2-diamines, e.g. ethylenediamine and cis-(and trans-)1,2-diaminocyclohexane, caused [4+2] cyclocondensation to give the corresponding dihydropyrazine derivatives (compounds 1-6). They exhibited stronger DNA strand-breakage activity than that of dihydropyrazines, which has already been reported in previous papers.Entities:
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Year: 2005 PMID： 16205004 DOI： 10.1248/cpb.53.1359
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645