Literature DB >> 16204994

Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum.

Apichart Suksamrarn1, Matee Buaprom, Saifon Udtip, Nuchnipa Nuntawong, Rachada Haritakun, Somdej Kanokmedhakul.   

Abstract

From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, beta-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, beta-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 microg/ml and showed antiplasmodial activity with an IC50 value of 7.2 microg/ml. Compounds 2 and 3 were inactive in both assays.

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Year:  2005        PMID： 16204994     DOI： 10.1248/cpb.53.1327

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  8 in total

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Review 3.  New advances in fatty acids as antimalarial, antimycobacterial and antifungal agents.

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Review 4.  Recent developments in the antiprotozoal and anticancer activities of the 2-alkynoic fatty acids.

Authors:  Néstor M Carballeira
Journal:  Chem Phys Lipids       Date:  2013-05-28       Impact factor: 3.329

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6.  Computer aided screening of potent inhibitor compounds against inhibitor resistant TEM β-lactamase mutants from traditional Chinese medicine.

Authors:  Qifeng Zhu; Yanxia Yin; Hanjie Liu; Jinhong Tian
Journal:  Bioinformation       Date:  2014-12-31

7.  Antimalarial and antiplasmodial activity of husk extract and fractions of Zea mays.

Authors:  Jude E Okokon; Bassey S Antia; Dinesh Mohanakrishnan; Dinkar Sahal
Journal:  Pharm Biol       Date:  2017-12       Impact factor: 3.503

8.  Antimalarial, antiplasmodial and analgesic activities of root extract of Alchornea laxiflora.

Authors:  Jude E Okokon; Nkemnele Bensella Augustine; Dinesh Mohanakrishnan
Journal:  Pharm Biol       Date:  2017-12       Impact factor: 3.503
  8 in total

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