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Literature DB >> 16204969

Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritis.

Yoshiko Ikawa¹, Masahiko Suzuki, Satoshi Shiono, Emi Ohki, Hideshige Moriya, Etsuko Negishi, Koichi Ueno.

Abstract

While histamine H4 receptor (H4R) has been implicated in immune system disturbances in different organ tissues, the presence and possible roles of H4R in synovial cells (SC) of rheumatoid arthritis (RA) patients has not previously been documented. This study conclusively evidences H4R expression in SC of RA patients by use of RT-PCR method. As RA consists mainly of immunological disturbances in SC of RA patients, this study's findings document a novel histamine action site, and opens potential new avenues to investigate mechanisms and to develop pharmacotherapeutic agents for the disease.

Entities: Chemical Disease Gene Species

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Year: 2005 PMID： 16204969 DOI： 10.1248/bpb.28.2016

Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233

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Cited

8 in total

Review 1. The role of histamine H4 receptor in immune and inflammatory disorders.

Authors: E Zampeli; E Tiligada
Journal: Br J Pharmacol Date: 2009-03-20 Impact factor: 8.739

2. Lower expression of histamine H₄ receptor in synovial tissues from patients with rheumatoid arthritis compared to those with osteoarthritis.

Authors: Katsunori Yamaura; Manabu Oda; Masahiko Suzuki; Koichi Ueno
Journal: Rheumatol Int Date: 2011-09-01 Impact factor: 2.631

3. The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils.

Authors: Karim Dib; Tomas Perecko; Veronika Jenei; Cheryl McFarlane; David Comer; Vanessa Brown; Mwape Katebe; Torsten Scheithauer; Robin L Thurmond; Paul L Chazot; Madeleine Ennis
Journal: J Leukoc Biol Date: 2014-05-05 Impact factor: 4.962

4. Toreforant, an orally active histamine H₄-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.

Authors: David L Boyle; Samuel E DePrimo; Cesar Calderon; Dion Chen; Paul J Dunford; William Barchuk; Gary S Firestein; Robin L Thurmond
Journal: Inflamm Res Date: 2019-02-09 Impact factor: 4.575

Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritis.

Review 1. The role of histamine H4 receptor in immune and inflammatory disorders.

2. Lower expression of histamine H₄ receptor in synovial tissues from patients with rheumatoid arthritis compared to those with osteoarthritis.

3. The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils.

4. Toreforant, an orally active histamine H₄-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.

Review 5. International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.

6. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.

7. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.

8. Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis.

Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritis.

Review 1. The role of histamine H4 receptor in immune and inflammatory disorders.

2. Lower expression of histamine H₄ receptor in synovial tissues from patients with rheumatoid arthritis compared to those with osteoarthritis.

3. The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils.

4. Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.

Review 5. International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.

6. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.

7. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.

8. Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis.

4. Toreforant, an orally active histamine H₄-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.