Literature DB >> 16204965

CYP3A4 inhibitors isolated from Licorice.

Sachiko Tsukamoto1, Maki Aburatani, Tomohiro Yoshida, Yuko Yamashita, Ahmed Atef El-Beih, Tomihisa Ohta.   

Abstract

The extract of licorice (Glycyrrhiza uralensis FISHER, Leguminosae) showed CYP3A4 inhibitory activity with the IC50 value of 0.022 mg/ml. Bioassay-guided purification afforded nine compounds, 3-(p-hydroxyphenyl)propionic acid (1), isoliquiritigenin (2), (3R)-vestitol (3), licopyranocoumarin (4), 4-hydroxyguaiacol apioglucoside (5), liquiritin (6), liquiritigenin 7,4'-diglucoside (7), liquiritin apioside (8), and glucoliquiritin apioside (9). Among these compounds, 3, 7, and 5 showed potent CYP3A4 inhibitory activities with IC50 values of 3.6, 17, and 20 microM, respectively. Glycyrrhizin (10), a main constituent of licorice, however, was inactive for CYP3A4 inhibition.

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Year:  2005        PMID： 16204965     DOI： 10.1248/bpb.28.2000

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  12 in total

1.  Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents.

Authors:  Guannan Li; Charlotte Simmler; Luying Chen; Dejan Nikolic; Shao-Nong Chen; Guido F Pauli; Richard B van Breemen
Journal:  Eur J Pharm Sci       Date:  2017-07-31       Impact factor: 4.384

2.  Population pharmacokinetics of sirolimus in de novo Chinese adult renal transplant patients.

Authors:  Zheng Jiao; Xiao-jin Shi; Zhong-dong Li; Ming-kang Zhong
Journal:  Br J Clin Pharmacol       Date:  2009-07       Impact factor: 4.335

3.  Licorice abuse: time to send a warning message.

Authors:  Hesham R Omar; Irina Komarova; Mohamed El-Ghonemi; Ahmed Fathy; Rania Rashad; Hany D Abdelmalak; Muralidhar Reddy Yerramadha; Yaseen Ali; Engy Helal; Enrico M Camporesi
Journal:  Ther Adv Endocrinol Metab       Date:  2012-08       Impact factor: 3.565

Review 4.  Review on prescription compatibility of shaoyao gancao decoction and reflection on pharmacokinetic compatibility mechanism of traditional chinese medicine prescription based on in vivo drug interaction of main efficacious components.

Authors:  Xiaolin Bi; Meirong Gong; Liuqing Di
Journal:  Evid Based Complement Alternat Med       Date:  2014-07-23       Impact factor: 2.629

5.  Inhibition of Cytochrome P450 (CYP3A4) Activity by Extracts from 57 Plants Used in Traditional Chinese Medicine (TCM).

Authors:  Mohamed L Ashour; Fadia S Youssef; Haidy A Gad; Michael Wink
Journal:  Pharmacogn Mag       Date:  2017-04-18       Impact factor: 1.085

Review 6.  Bioactive Candy: Effects of Licorice on the Cardiovascular System.

Authors:  Mikkel R Deutch; Daniela Grimm; Markus Wehland; Manfred Infanger; Marcus Krüger
Journal:  Foods       Date:  2019-10-14

7.  Identification of small molecule activators of BMP signaling.

Authors:  Karen Vrijens; Wenwei Lin; Jimmy Cui; Dana Farmer; Jonathan Low; Elodie Pronier; Fu-Yue Zeng; Anang A Shelat; Kiplin Guy; Michael R Taylor; Taosheng Chen; Martine F Roussel
Journal:  PLoS One       Date:  2013-03-19       Impact factor: 3.240

8.  Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease.

Authors:  Takahiro Fujimaki; Shinji Saiki; Etsu Tashiro; Daisuke Yamada; Mitsuhiro Kitagawa; Nobutaka Hattori; Masaya Imoto
Journal:  PLoS One       Date:  2014-06-24       Impact factor: 3.240

Review 9.  Herbal Bioenhancers in Veterinary Phytomedicine.

Authors:  Begum Yurdakok-Dikmen; Yagmur Turgut; Ayhan Filazi
Journal:  Front Vet Sci       Date:  2018-10-10

Review 10.  Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds.

Authors:  Marjan Nassiri Asl; Hossein Hosseinzadeh
Journal:  Phytother Res       Date:  2008-06       Impact factor: 5.878
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