Literature DB >> 16204018

The transcription factor Pokemon: a new key player in cancer pathogenesis.

Takahiro Maeda1, Robin M Hobbs, Pier Paolo Pandolfi.   

Abstract

Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.

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Year:  2005        PMID： 16204018     DOI： 10.1158/0008-5472.CAN-05-1055

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  39 in total

1.  MicroRNA (miRNA)-mediated interaction between leukemia/lymphoma-related factor (LRF) and alternative splicing factor/splicing factor 2 (ASF/SF2) affects mouse embryonic fibroblast senescence and apoptosis.

Authors:  Lorena Verduci; Marcella Simili; Milena Rizzo; Alberto Mercatanti; Monica Evangelista; Laura Mariani; Giuseppe Rainaldi; Letizia Pitto
Journal:  J Biol Chem       Date:  2010-10-04       Impact factor: 5.157

2.  Pokemon enhances proliferation, cell cycle progression and anti-apoptosis activity of colorectal cancer independently of p14ARF-MDM2-p53 pathway.

Authors:  Yi Zhao; Yun-hong Yao; Li Li; Wei-fang An; Hong-zen Chen; Li-ping Sun; Hai-xian Kang; Sen Wang; Xin-rong Hu
Journal:  Med Oncol       Date:  2014-11-04       Impact factor: 3.064

3.  Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.

Authors:  Kaori Tsuji-Takechi; Takako Negishi-Koga; Eriko Sumiya; Akiko Kukita; Shigeaki Kato; Takahiro Maeda; Pier Paolo Pandolfi; Keiji Moriyama; Hiroshi Takayanagi
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205

4.  Resveratrol Represses Pokemon Expression in Human Glioma Cells.

Authors:  Yutao Yang; Jiajun Cui; Feng Xue; Anne-Marie Overstreet; Yiping Zhan; Dapeng Shan; Hui Li; Hui Li; Yongjun Wang; Mengmeng Zhang; Chunjiang Yu; Zhi-Qing David Xu
Journal:  Mol Neurobiol       Date:  2015-01-27       Impact factor: 5.590

5.  Structure of the wild-type human BCL6 POZ domain.

Authors:  Mark A Stead; Gareth O Rosbrook; Jonathan M Hadden; Chi H Trinh; Stephen B Carr; Stephanie C Wright
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-11-28

6.  Expression of leukemia/lymphoma-related factor (LRF/POKEMON) in human breast carcinoma and other cancers.

Authors:  Anshu Aggarwal; William J Hunter; Himanshu Aggarwal; Edibaldo D Silva; Mary S Davey; Richard F Murphy; Devendra K Agrawal
Journal:  Exp Mol Pathol       Date:  2010-05-21       Impact factor: 3.362

7.  Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors.

Authors:  Bu-Nam Jeon; Jung-Yoon Yoo; Won-Il Choi; Choong-Eun Lee; Ho-Geun Yoon; Man-Wook Hur
Journal:  J Biol Chem       Date:  2008-09-18       Impact factor: 5.157

8.  Curcumin decreases the expression of Pokemon by suppressing the binding activity of the Sp1 protein in human lung cancer cells.

Authors:  Jiajun Cui; Xianfeng Meng; Xudong Gao; Guangxuan Tan
Journal:  Mol Biol Rep       Date:  2009-05-15       Impact factor: 2.316

9.  P-Glycoprotein/MDR1 regulates pokemon gene transcription through p53 expression in human breast cancer cells.

Authors:  Shengnan He; Feng Liu; Zhenhua Xie; Xuyu Zu; Wei Xu; Yuyang Jiang
Journal:  Int J Mol Sci       Date:  2010-08-27       Impact factor: 5.923

10.  A significant increase of RNAi efficiency in human cells by the CMV enhancer with a tRNAlys promoter.

Authors:  Ma Weiwei; Xie Zhenhua; Liu Feng; Ning Hang; Jiang Yuyang
Journal:  J Biomed Biotechnol       Date:  2009-10-25
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