Literature DB >> 16203151

The benefits of the multi-target approach in drug design and discovery.

L Michel Espinoza-Fonseca1.   

Abstract

Promiscuous binding has been considered to be a problem in the design and development of new drugs against a given disease. However, promiscuity in molecular recognition is not all bad news, and scientists are currently taking advantage of the emerging 'promiscuous binding' or 'multi-target approach' in medicinal chemistry.

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Year:  2005        PMID： 16203151     DOI： 10.1016/j.bmc.2005.09.011

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  31 in total

1.  Systematic analysis of gene properties influencing organ system phenotypes in mammalian perturbations.

Authors:  Ingo Vogt; Jeanette Prinz; Karolina Worf; Monica Campillos
Journal:  Bioinformatics       Date:  2014-07-23       Impact factor: 6.937

2.  Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity.

Authors:  L W Lawrence Woo; Christian Bubert; Atul Purohit; Barry V L Potter
Journal:  ACS Med Chem Lett       Date:  2010-12-29       Impact factor: 4.345

3.  Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: a novel class of potent cytotoxins.

Authors:  Swagatika Das; Umashankar Das; Armando Varela-Ramírez; Carolina Lema; Renato J Aguilera; Jan Balzarini; Erik De Clercq; Stephen G Dimmock; Dennis K J Gorecki; Jonathan R Dimmock
Journal:  ChemMedChem       Date:  2011-08-08       Impact factor: 3.466

Review 4.  1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.

Authors:  U Das; R K Sharma; J R Dimmock
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530

5.  The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones.

Authors:  Hari N Pati; Umashankar Das; Swagatika Das; Brian Bandy; Erik De Clercq; Jan Balzarini; Masami Kawase; Hiroshi Sakagami; J Wilson Quail; James P Stables; Jonathan R Dimmock
Journal:  Eur J Med Chem       Date:  2008-03-29       Impact factor: 6.514

6.  Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.

Authors:  Laura González-Lafuente; Javier Egea; Rafael León; Francisco J Martínez-Sanz; Leticia Monjas; Concepción Perez; Cristina Merino; Antonio M García-De Diego; María I Rodríguez-Franco; Antonio G García; Mercedes Villarroya; Manuela G López; Cristóbal de Los Ríos
Journal:  ACS Chem Neurosci       Date:  2012-03-26       Impact factor: 4.418

7.  Consolidation of network and experimental pharmacology to divulge the antidiabetic action of Ficus benghalensis L. bark.

Authors:  Pukar Khanal; B M Patil
Journal:  3 Biotech       Date:  2021-04-25       Impact factor: 2.406

8.  Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates.

Authors:  Paul M Wood; L W Lawrence Woo; Mark P Thomas; Mary F Mahon; Atul Purohit; Barry V L Potter
Journal:  ChemMedChem       Date:  2011-05-23       Impact factor: 3.466

9.  Synthesis and preliminary anti-inflammatory and anti-bacterial evaluation of some diflunisal aza-analogs.

Authors:  Davide Carta; Paola Brun; Matteo Dal Pra; Giulia Bernabè; Ignazio Castagliuolo; Maria Grazia Ferlin
Journal:  Medchemcomm       Date:  2018-04-24       Impact factor: 3.597

10.  Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.

Authors:  Areej Abuhammad; Elizabeth Fullam; Edward D Lowe; David Staunton; Akane Kawamura; Isaac M Westwood; Sanjib Bhakta; Alun Christopher Garner; David L Wilson; Peter T Seden; Stephen G Davies; Angela J Russell; Elspeth F Garman; Edith Sim
Journal:  PLoS One       Date:  2012-12-28       Impact factor: 3.240
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