| Literature DB >> 16203136 |
Anil Vasudevan1, Andrew J Souers, Jennifer C Freeman, Mary K Verzal, Ju Gao, Mathew M Mulhern, Derek Wodka, John K Lynch, Kenneth M Engstrom, Seble H Wagaw, Sevan Brodjian, Brian Dayton, Doug H Falls, Eugene Bush, Michael Brune, Robin D Shapiro, Kennan C Marsh, Lisa E Hernandez, Christine A Collins, Philip R Kym.
Abstract
The synthesis and biological evaluation of novel 3-amino indazole melanin concentrating hormone receptor-1 antagonists are reported, several of which demonstrated functional activity of less than 100nM. Compounds 19 and 28, two of the more potent compounds identified in this study, were characterized by high exposure in the brain and demonstrated robust efficacy when dosed in diet-induced obese mice.Entities:
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Year: 2005 PMID： 16203136 DOI： 10.1016/j.bmcl.2005.08.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823