| Literature DB >> 16202593 |
Laura L Rokosz1, Chia-Yu Huang, John C Reader, Tara M Stauffer, Daniel Chelsky, Nolan H Sigal, Ashit K Ganguly, John J Baldwin.
Abstract
In order to fully explore structure-activity relationships at the 1- and 2-positions of the piperazine core of tricyclic farnesyltransferase inhibitors, an 11,718-member ECLiPS library was synthesized and screened in a farnesyltransferase scintillation proximity assay. A detailed description of the library and analyses of the screening data will be provided.Entities:
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Year: 2005 PMID： 16202593 DOI： 10.1016/j.bmcl.2005.08.074
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823