Literature DB >> 1620239

NPY and carbachol raise Ca2+ in SK-N-MC cells by three different mechanisms. Evidence for inositol phosphate-independent Ca2+ mobilization by NPY.

M C Michel1, F Feth, M Stieneker, W Rascher.   

Abstract

We have compared the mechanism of NPY- and carbachol-stimulated Ca2+ increases in SK-N-MC cells. NPY stimulated Ca2+ mobilization via a pertussis toxin-sensitive mechanism. Carbachol stimulated Ca2+ mobilization and influx via pertussis toxin-insensitive and -sensitive mechanisms, respectively. Carbachol but not NPY stimulated inositol phosphate accumulation by a pertussis toxin-insensitive mechanism. We conclude that carbachol promotes Ca2+ influx via a pertussis toxin-sensitive G protein and Ca2+ mobilization via a pertussis toxin-insensitive G-protein coupling to inositol phosphate generation; NPY stimulates Ca2+ mobilization via a pertussis toxin-sensitive G protein without apparent involvement of inositol phosphates.

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Year:  1992        PMID： 1620239     DOI： 10.1007/bf00176612

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  19 in total

1.  Receptor-mediated inositol phosphate formation in relation to calcium mobilization: a comparison of two cell lines.

Authors:  S K Ambler; B Thompson; P A Solski; J H Brown; P Taylor
Journal:  Mol Pharmacol       Date:  1987-09       Impact factor: 4.436

2.  Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate.

Authors:  G S Bird; M F Rossier; A R Hughes; S B Shears; D L Armstrong; J W Putney
Journal:  Nature       Date:  1991-07-11       Impact factor: 49.962

Review 3.  Receptors for neuropeptide Y: multiple subtypes and multiple second messengers.

Authors:  M C Michel
Journal:  Trends Pharmacol Sci       Date:  1991-10       Impact factor: 14.819

4.  Coupling of transfected muscarinic acetylcholine receptor subtypes to phospholipase D.

Authors:  J Sandmann; E G Peralta; R J Wurtman
Journal:  J Biol Chem       Date:  1991-04-05       Impact factor: 5.157

5.  Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase.

Authors:  L Aakerlund; U Gether; J Fuhlendorff; T W Schwartz; O Thastrup
Journal:  FEBS Lett       Date:  1990-01-15       Impact factor: 4.124

6.  [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist.

Authors:  J Fuhlendorff; U Gether; L Aakerlund; N Langeland-Johansen; H Thøgersen; S G Melberg; U B Olsen; O Thastrup; T W Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

7.  Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

Authors:  O Thastrup; P J Cullen; B K Drøbak; M R Hanley; A P Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

8.  Two different G-proteins mediate neuropeptide Y and bradykinin-stimulated phospholipid breakdown in cultured rat sensory neurons.

Authors:  T M Perney; R J Miller
Journal:  J Biol Chem       Date:  1989-05-05       Impact factor: 5.157

9.  NPY-stimulated Ca2+ mobilization in SK-N-MC cells is enhanced after isoproterenol treatment.

Authors:  M C Michel; F Feth; W Rascher
Journal:  Am J Physiol       Date:  1992-04

10.  Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation.

Authors:  D H Carney; D L Scott; E A Gordon; E F LaBelle
Journal:  Cell       Date:  1985-09       Impact factor: 41.582
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  4 in total

1.  Differential calcium signalling by m2 and m3 muscarinic acetylcholine receptors in a single cell type.

Authors:  M Schmidt; C Bienek; C J van Koppen; M C Michel; K H Jakobs
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-11       Impact factor: 3.000

2.  Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells.

Authors:  D Meyer zu Heringdrof; C J van Koppen; B Windorfer; H M Himmel; K H Jakobs
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-10       Impact factor: 3.000

3.  Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization.

Authors:  Damien S K Samways; Wen-hong Li; Stuart J Conway; Andrew B Holmes; Martin D Bootman; Graeme Henderson
Journal:  Biochem J       Date:  2003-11-01       Impact factor: 3.857

4.  The modulatory effects of endothelin-1, carbachol and isoprenaline upon Na(+)-H+ exchange in dog cardiac Purkinje fibres.

Authors:  M L Wu; Y Z Tseng
Journal:  J Physiol       Date:  1993-11       Impact factor: 5.182
  4 in total

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