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Literature DB >> 16201295

Association of HLA-DRB1, DQB1 alleles with chronic urticaria.

Jing Chen¹, Zhijian Tan, Jiawen Li, Ping Xiong.

Abstract

In order to investigate the association of genotypes of HLA-DRB1 and HLA-DQB1 alleles with the genetic susceptibility of chronic urticaria (CU), genotypes of HLA-DRB1 and HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with CU (19 men and 23 women, mean age 30.67+/-12.45 y old as well as 193 racially matched healthy persons in ethnic Han from Hubei provinece. Gene frequencies of HLA-DRB1 * 12, * 0901 (RR=3.11, chi2=7. 579, P=0.006; RR= 2.47, chi2 =5.684, P=0.017) were significantly increased in CU patients as compared with that in healthy people. Gene frequencies of HLA-DQB1 * 05 (RR=0.26, chi2=6.683, P=0.01) were significantly decreased in CU patients. It was suggested that CU was found strongly associated with HLA-DRB1 * 12, * 0901 and HLA-DQB1 * 05, the former might be the genetic markers for susceptibility to CU, but the latter might play a resistive role.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16201295 DOI： 10.1007/bf02828166

Source DB: PubMed Journal: J Huazhong Univ Sci Technolog Med Sci ISSN： 1672-0733

16 in total

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Journal: Tissue Antigens Date: 1995-11

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8. Is there any relationship between human leucocyte antigen class II and chronic urticaria? (chronic urticaria and HLA class II).

Authors: Pinar Oztas; Meltem Onder; Sevim Gonen; Murat Orhan Oztas; Oguz Soylemezoglu
Journal: Yonsei Med J Date: 2004-06-30 Impact factor: 2.759

Association of HLA-DRB1, DQB1 alleles with chronic urticaria.

1. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation.

2. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP).

3. Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: a study of 90 patients.

4. Human leucocyte antigen class II associations in chronic idiopathic urticaria.

5. Lack of linkage between hereditary angioedema and the A and B loci of the HLA system.

6. The HLA-DQ associations with Graves' disease in Chinese children.

7. HLA and lymphocyte histamine sensitivity in mastocytosis.

8. Is there any relationship between human leucocyte antigen class II and chronic urticaria? (chronic urticaria and HLA class II).

9. [Symptomatic dermatographism and HLA antigens].

10. Chronic idiopathic urticaria: a family study.

Review 1. Molecular genetic mechanisms of chronic urticaria.

Review 2. Autoimmune Theories of Chronic Spontaneous Urticaria.

3. The association between chronic spontaneous urticaria and HLA class I and class II antigen