Literature DB >> 16201278

Effects of intestinal trefoil, factor on colonic mucosa in experimental colitis of rats.

Tian Yang1, Kaifang Zou, Wei Qian.   

Abstract

In order to investigate the protective effects of intestinal trefoil factor (ITF) on colonic mucosa in experimental colitis of rats, ITF was detected by RT-PCR and immunohistochemistry at different time points. Three days after colitis induction, rats were treated with either 0.9% saline solution or rhITF. Pathological changes and the expression of iNOS mRNA, NO, MDA and SOD were measured respectively. It was found that ITF was mainly located in goblet cells, significantly higher in model group than in normal group (P<0.05). rhITF could increase the iNOS mRNA expression and NO contents, and there was statistically significant difference between rhITF group and model group (P<0.05). rhITF also caused an increase of MDA and a decrease of SOD, but there was no significant difference between two groups. These results indicated that ITF has apparent therapeutic effects in ulcerative colitis, which may be associated with iNOS and NO.

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Year:  2005        PMID： 16201278     DOI： 10.1007/bf02828149

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  10 in total

Review 1.  Trefoil peptides.

Authors:  W M Wong; R Poulsom; N A Wright
Journal:  Gut       Date:  1999-06       Impact factor: 23.059

2.  Effect of trefoil factors on the viscoelastic properties of mucus gels.

Authors:  L Thim; F Madsen; S S Poulsen
Journal:  Eur J Clin Invest       Date:  2002-07       Impact factor: 4.686

Review 3.  Nitric oxide in inflammatory bowel disease.

Authors:  Raymond K Cross; Keith T Wilson
Journal:  Inflamm Bowel Dis       Date:  2003-05       Impact factor: 5.325

4.  Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis.

Authors:  C P Tran; G A Cook; N D Yeomans; L Thim; A S Giraud
Journal:  Gut       Date:  1999-05       Impact factor: 23.059

5.  Nitric oxide supplementation ameliorates dextran sulfate sodium-induced colitis in mice.

Authors:  Azucena Salas; Meritxell Gironella; Antonio Salas; Antonio Soriano; Miquel Sans; Juan Iovanna; Josep M Piqué; Julián Panés
Journal:  Lab Invest       Date:  2002-05       Impact factor: 5.662

6.  Intestinal motility in an in vivo rat model of intestinal ischemia-reperfusion with special reference to the effects of nitric oxide on the motility changes.

Authors:  A Takahashi; T Tomomasa; H Kaneko; T Watanabe; M Tabata; H Morikawa; Y Tsuchida; H Kuwano
Journal:  J Pediatr Gastroenterol Nutr       Date:  2001-09       Impact factor: 2.839

7.  Inhibition of nitric oxide synthesis by aminoguanidine increases intestinal damage in the acute phase of rat TNB-colitis.

Authors:  N Dikopoulos; A K Nüssler; S Liptay; M Bachem; M Reinshagen; M Stiegler; R M Schmid; G Adler; H Weidenbach
Journal:  Eur J Clin Invest       Date:  2001-03       Impact factor: 4.686

8.  Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis.

Authors:  A D Millar; D S Rampton; C L Chander; A W Claxson; S Blades; A Coumbe; J Panetta; C J Morris; D R Blake
Journal:  Gut       Date:  1996-09       Impact factor: 23.059

9.  TFF-2 inhibits iNOS/NO in monocytes, and nitrated protein in healing colon after colitis.

Authors:  Andrew S Giraud; Prue M Pereira; Lars Thim; Lorraine M Parker; Louise M Judd
Journal:  Peptides       Date:  2004-05       Impact factor: 3.750

10.  Distinct epithelial responses in experimental colitis: implications for ion uptake and mucosal protection.

Authors:  Ingrid B Renes; Melissa Verburg; Daniëlle J P M Van Nispen; Hans A Büller; Jan Dekker; Alexandra W C Einerhand
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2002-07       Impact factor: 4.052
  10 in total

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