Literature DB >> 1620105

High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors.

K R Thomas1, C Deng, M R Capecchi.   

Abstract

Mutations were targeted to the Hprt locus in murine embryonic stem cells by using sequence replacement vectors. When the vector was designed such that the mutated sequences were flanked on both sides by several kilobases of DNA homologous to the target locus, replacement of chromosomal sequences with the exogenous DNA occurred with precision. If, on the other hand, the target-homologous DNA on one arm of the vector was reduced to below 1 kb in length, the fidelity of recombination was diminished.

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Year:  1992        PMID： 1620105      PMCID： PMC364504          DOI： 10.1128/mcb.12.7.2919-2923.1992

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  25 in total

1.  Homologous recombination in hybridoma cells: heavy chain chimeric antibody produced by gene targeting.

Authors:  H P Fell; S Yarnold; I Hellström; K E Hellström; K R Folger
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

2.  Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

Authors:  B H Koller; P Marrack; J W Kappler; O Smithies
Journal:  Science       Date:  1990-06-08       Impact factor: 47.728

3.  Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.

Authors:  K R Thomas; M R Capecchi
Journal:  Nature       Date:  1986 Nov 6-12       Impact factor: 49.962

4.  The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.

Authors:  A P McMahon; A Bradley
Journal:  Cell       Date:  1990-09-21       Impact factor: 41.582

5.  Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

Authors:  K R Thomas; M R Capecchi
Journal:  Nature       Date:  1990-08-30       Impact factor: 49.962

6.  Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs.

Authors:  R L Brinster; R E Braun; D Lo; M R Avarbock; F Oram; R D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

7.  Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.

Authors:  P L Schwartzberg; E J Robertson; S P Goff
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

8.  Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

Authors:  D W Melton; D S Konecki; J Brennand; C T Caskey
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

9.  Targeted mutation of the Hprt gene in mouse embryonic stem cells.

Authors:  T Doetschman; N Maeda; O Smithies
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

10.  A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

Authors:  T M DeChiara; A Efstratiadis; E J Robertson
Journal:  Nature       Date:  1990-05-03       Impact factor: 49.962
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  46 in total

1.  The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.

Authors:  L J Niedernhofer; J Essers; G Weeda; B Beverloo; J de Wit; M Muijtjens; H Odijk; J H Hoeijmakers; R Kanaar
Journal:  EMBO J       Date:  2001-11-15       Impact factor: 11.598

2.  Chromosomal integration pattern of a helper-dependent minimal adenovirus vector with a selectable marker inserted into a 27.4-kilobase genomic stuffer.

Authors:  M Hillgenberg; H Tönnies; M Strauss
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

3.  Mechanisms involved in targeted gene replacement in mammalian cells.

Authors:  J Li; M D Baker
Journal:  Genetics       Date:  2000-10       Impact factor: 4.562

4.  Ends-out, or replacement, gene targeting in Drosophila.

Authors:  Wei J Gong; Kent G Golic
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-14       Impact factor: 11.205

5.  Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse.

Authors:  Michelle L Gottsch; Simina M Popa; Janessa K Lawhorn; Jian Qiu; Karen J Tonsfeldt; Martha A Bosch; Martin J Kelly; Oline K Rønnekleiv; Elisenda Sanz; G Stanley McKnight; Donald K Clifton; Richard D Palmiter; Robert A Steiner
Journal:  Endocrinology       Date:  2011-09-20       Impact factor: 4.736

6.  Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus.

Authors:  C Deng; M R Capecchi
Journal:  Mol Cell Biol       Date:  1992-08       Impact factor: 4.272

Review 7.  Cre recombinase mediated alterations of the mouse genome using embryonic stem cells.

Authors:  Anna-Katerina Hadjantonakis; Melinda Pirity; András Nagy
Journal:  Methods Mol Biol       Date:  2008

8.  Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.

Authors:  R V Farese; S L Ruland; L M Flynn; R P Stokowski; S G Young
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

9.  Nascent DNA synthesis during homologous recombination is synergistically promoted by the rad51 recombinase and DNA homology.

Authors:  Maureen M Mundia; Vatsal Desai; Alissa C Magwood; Mark D Baker
Journal:  Genetics       Date:  2014-02-28       Impact factor: 4.562

10.  Testing predictions of the double-strand break repair model relating to crossing over in Mammalian cells.

Authors:  Erin C Birmingham; Shauna A Lee; Richard D McCulloch; Mark D Baker
Journal:  Genetics       Date:  2004-11       Impact factor: 4.562
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