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Literature DB >> 1620103

The two genes encoding protein synthesis initiation factor eIF-5A in Saccharomyces cerevisiae are members of a duplicated gene cluster.

H A Kang¹, H G Schwelberger, J W Hershey.

Abstract

Translation initiation factor eIF-5A is an abundant protein in which a lysine residue is modified by spermidine to form the amino acid derivative, hypusine. The factor is encoded by two genes in Saccharomyces cerevisiae, called TIF51A and TIF51B, which are regulated reciprocally by oxygen and by heme. TIF51B, also called ANB1, is located on chromosome X in a region called COR. We physically mapped TIF51A and its associated serine tRNA2 gene by the method of chromosome fragmentation and pulsed-field gel electrophoresis. TIF51A maps 90 kb from the left end of chromosome V in a region called ARC. The COR and ARC regions contain CYC1 and CYC7, respectively, and appear to be duplications carrying numerous related genes. The arrangements of related genes in the two regions are incompatible with a duplication mechanism involving a circular intermediate.

Entities: Chemical Gene Species

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Year: 1992 PMID： 1620103 DOI： 10.1007/bf00265449

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

13 in total

1. The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication.

Authors: S I Gibson; R T Surosky; B K Tye
Journal: Mol Cell Biol Date: 1990-11 Impact factor: 4.272

The two genes encoding protein synthesis initiation factor eIF-5A in Saccharomyces cerevisiae are members of a duplicated gene cluster.

1. The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication.

2. ROX1 encodes a heme-induced repression factor regulating ANB1 and CYC7 of Saccharomyces cerevisiae.

3. An extensive deletion causing overproduction of yeast iso-2-cytochrome c.

4. Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes.

5. Physical mapping of large DNA by chromosome fragmentation.

6. Nucleotide sequence of the COR region: a cluster of six genes in the yeast Saccharomyces cerevisiae.

7. The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF-4D.

8. Modulator sequences mediate oxygen regulation of CYC1 and a neighboring gene in yeast.

9. Protease B of Saccharomyces cerevisiae: isolation and regulation of the PRB1 structural gene.

10. Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D.

1. Combinatorial repression of the hypoxic genes of Saccharomyces cerevisiae by DNA binding proteins Rox1 and Mot3.

2. The function of the hypusine-containing proteins of yeast and other eukaryotes is well conserved.

3. Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein.

4. Multiple genes encode the translation elongation factor EF-1 gamma in Saccharomyces cerevisiae.

Review 5. Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?

Review 6. Roles of eukaryotic initiation factor 5A2 in human cancer.