Literature DB >> 16200198

Pharmacological manipulation of Bcl-2 family members to control cell death.

Anthony Letai1.   

Abstract

The commitment to programmed cell death involves complex interactions among pro- and antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision by these proteins to undergo cell death is permeabilization of the mitochondrial outer membrane. Pharmacologic manipulation of proteins in this family appears both feasible and efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or brain, or increased cell death, as in cancer.

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Year:  2005        PMID： 16200198      PMCID： PMC1236690          DOI： 10.1172/JCI26250

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  118 in total

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Authors:  Shinichi Kitada; Marilisa Leone; Sina Sareth; Dayong Zhai; John C Reed; Maurizio Pellecchia
Journal:  J Med Chem       Date:  2003-09-25       Impact factor: 7.446

2.  Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.

Authors:  X Liu; C N Kim; J Yang; R Jemmerson; X Wang
Journal:  Cell       Date:  1996-07-12       Impact factor: 41.582

3.  Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

Authors:  Tomomi Kuwana; Mason R Mackey; Guy Perkins; Mark H Ellisman; Martin Latterich; Roger Schneiter; Douglas R Green; Donald D Newmeyer
Journal:  Cell       Date:  2002-11-01       Impact factor: 41.582

4.  Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1.

Authors:  P F Dijkers; R H Medema; J W Lammers; L Koenderman; P J Coffer
Journal:  Curr Biol       Date:  2000-10-05       Impact factor: 10.834

5.  Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

Authors:  A M Verhagen; P G Ekert; M Pakusch; J Silke; L M Connolly; G E Reid; R L Moritz; R J Simpson; D L Vaux
Journal:  Cell       Date:  2000-07-07       Impact factor: 41.582

6.  BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.

Authors:  E H Cheng; M C Wei; S Weiler; R A Flavell; T W Mak; T Lindsten; S J Korsmeyer
Journal:  Mol Cell       Date:  2001-09       Impact factor: 17.970

7.  Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

Authors:  S P Tzung; K M Kim; G Basañez; C D Giedt; J Simon; J Zimmerberg; K Y Zhang; D M Hockenbery
Journal:  Nat Cell Biol       Date:  2001-02       Impact factor: 28.824

8.  Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

Authors:  Joseph T Opferman; Anthony Letai; Caroline Beard; Mia D Sorcinelli; Christy C Ong; Stanley J Korsmeyer
Journal:  Nature       Date:  2003-12-11       Impact factor: 49.962

9.  bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

Authors:  L H Boise; M González-García; C E Postema; L Ding; T Lindsten; L A Turka; X Mao; G Nuñez; C B Thompson
Journal:  Cell       Date:  1993-08-27       Impact factor: 41.582

10.  Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo.

Authors:  M S Lawrence; D Y Ho; G H Sun; G K Steinberg; R M Sapolsky
Journal:  J Neurosci       Date:  1996-01-15       Impact factor: 6.167
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  37 in total

1.  Myrtenal attenuates diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades.

Authors:  Lingaiah Hari Babu; Srinivasan Perumal; Maruthaiveeran Periyasamy Balasubramanian
Journal:  Cell Oncol (Dordr)       Date:  2012-06-22       Impact factor: 6.730

Review 2.  Lipid raft: A floating island of death or survival.

Authors:  Kimberly S George; Shiyong Wu
Journal:  Toxicol Appl Pharmacol       Date:  2012-01-24       Impact factor: 4.219

Review 3.  Pharmacological manipulation of cell death: clinical applications in sight?

Authors:  Douglas R Green; Guido Kroemer
Journal:  J Clin Invest       Date:  2005-10       Impact factor: 14.808

4.  Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision.

Authors:  Chun Chen; Jun Cui; Haizhu Lu; Rui Wang; Shuai Zhang; Pingping Shen
Journal:  Biophys J       Date:  2007-03-30       Impact factor: 4.033

5.  BCNU/PLGA microspheres: a promising strategy for the treatment of gliomas in mice.

Authors:  Tongming Zhu; Yiwen Shen; Qisheng Tang; Luping Chen; Huasong Gao; Jianhong Zhu
Journal:  Chin J Cancer Res       Date:  2014-02       Impact factor: 5.087

6.  Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria.

Authors:  David Hermanson; Sadiya N Addo; Anna A Bajer; Jonathan S Marchant; Sonia Goutam Kumar Das; Balasubramanian Srinivasan; Fawaz Al-Mousa; Francesco Michelangeli; David D Thomas; Tucker W Lebien; Chengguo Xing
Journal:  Mol Pharmacol       Date:  2009-06-26       Impact factor: 4.436

Review 7.  Apoptotic pathways as a therapeutic target for colorectal cancer treatment.

Authors:  Aman M Abraha; Ezra B Ketema
Journal:  World J Gastrointest Oncol       Date:  2016-08-15

Review 8.  Genetic and pharmacological intervention for treatment/prevention of hearing loss.

Authors:  Douglas A Cotanche
Journal:  J Commun Disord       Date:  2008-03-25       Impact factor: 2.288

9.  Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.

Authors:  Nelly Buron; Mathieu Porceddu; Magali Brabant; Diana Desgué; Cindy Racoeur; Myriam Lassalle; Christine Péchoux; Pierre Rustin; Etienne Jacotot; Annie Borgne-Sanchez
Journal:  PLoS One       Date:  2010-03-31       Impact factor: 3.240

10.  Modeling the role of p53 pulses in DNA damage- induced cell death decision.

Authors:  Tingzhe Sun; Chun Chen; Yuanyuan Wu; Shuai Zhang; Jun Cui; Pingping Shen
Journal:  BMC Bioinformatics       Date:  2009-06-22       Impact factor: 3.169
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