OBJECTIVE: This study used functional magnetic resonance imaging to investigate amygdala response in patients with acute posttraumatic stress disorder (PTSD) to emotional expressions. METHOD: Thirteen medication-free individuals with acute PTSD and no axis I psychiatric comorbidity were scanned while viewing pictures of fearful or happy faces, presented above or below consciousness, with backward masking. RESULTS: There was a significant positive correlation between the severity of PTSD and the difference in amygdala responses between masked fearful and happy faces and a corresponding negative correlation for the difference between unmasked fearful and happy faces. CONCLUSIONS: These findings suggest that functional abnormalities in brain responses to emotional stimuli observed in chronic PTSD are already apparent in its acute phase.
OBJECTIVE: This study used functional magnetic resonance imaging to investigate amygdala response in patients with acute posttraumatic stress disorder (PTSD) to emotional expressions. METHOD: Thirteen medication-free individuals with acute PTSD and no axis I psychiatric comorbidity were scanned while viewing pictures of fearful or happy faces, presented above or below consciousness, with backward masking. RESULTS: There was a significant positive correlation between the severity of PTSD and the difference in amygdala responses between masked fearful and happy faces and a corresponding negative correlation for the difference between unmasked fearful and happy faces. CONCLUSIONS: These findings suggest that functional abnormalities in brain responses to emotional stimuli observed in chronic PTSD are already apparent in its acute phase.
Authors: Françoise S Maheu; Mary Dozier; Amanda E Guyer; Darcy Mandell; Elizabeth Peloso; Kaitlin Poeth; Jessica Jenness; Jennifer Y F Lau; John P Ackerman; Daniel S Pine; Monique Ernst Journal: Cogn Affect Behav Neurosci Date: 2010-03 Impact factor: 3.282
Authors: Erin B McClure; Abby Adler; Christopher S Monk; Jennifer Cameron; Samantha Smith; Eric E Nelson; Ellen Leibenluft; Monique Ernst; Daniel S Pine Journal: Psychopharmacology (Berl) Date: 2006-09-14 Impact factor: 4.530
Authors: Robert W Van Boven; Greg S Harrington; David B Hackney; Andreas Ebel; Grant Gauger; J Douglas Bremner; Mark D'Esposito; John A Detre; E Mark Haacke; Clifford R Jack; William J Jagust; Denis Le Bihan; Chester A Mathis; Susanne Mueller; Pratik Mukherjee; Norbert Schuff; Anthony Chen; Michael W Weiner Journal: J Rehabil Res Dev Date: 2009
Authors: Elizabeth A Osuch; Mark W Willis; Robyn Bluhm; Robert J Ursano; Wayne C Drevets Journal: Biol Psychiatry Date: 2008-08-15 Impact factor: 13.382
Authors: Christopher S Monk; Eva H Telzer; Karin Mogg; Brendan P Bradley; Xiaoqin Mai; Hugo M C Louro; Gang Chen; Erin B McClure-Tone; Monique Ernst; Daniel S Pine Journal: Arch Gen Psychiatry Date: 2008-05