Literature DB >> 16199599

Preimplantation HLA typing: having children to save our loved ones.

K Devolder1.   

Abstract

Preimplantation tissue typing has been proposed as a method for creating a tissue matched child that can serve as a haematopoietic stem cell donor to save its sick sibling in need of a stem cell transplant. Despite recent promising results, many people have expressed their disapproval of this method. This paper addresses the main concerns of these critics: the risk of preimplantation genetic diagnosis (PGD) for the child to be born; the intention to have a donor child; the limits that should be placed on what may be done to the donor child, and whether the intended recipient can be someone other than a sibling. The author will show that these concerns do not constitute a sufficient ground to forbid people to use this technique to save not only a sibling, but also any other loved one's life. Finally, the author briefly deals with two alternative scenarios: the creation of a human leukocyte antigen (HLA) matched child as an insurance policy, and the banking of HLA matched embryos.

Entities:  

Keywords:  Genetics and Reproduction

Mesh:

Substances:

Year:  2005        PMID: 16199599      PMCID: PMC1734026          DOI: 10.1136/jme.2004.010348

Source DB:  PubMed          Journal:  J Med Ethics        ISSN: 0306-6800            Impact factor:   2.903


  19 in total

Review 1.  Ethical issues and practical problems in preimplantation genetic diagnosis.

Authors:  J R Botkin
Journal:  J Law Med Ethics       Date:  1998       Impact factor: 1.718

2.  Taskforce 5: preimplantation genetic diagnosis.

Authors:  F Shenfield; G Pennings; P Devroey; C Sureau; B Tarlatzis; J Cohen
Journal:  Hum Reprod       Date:  2003-03       Impact factor: 6.918

3.  Conception to obtain hematopoietic stem cells.

Authors:  John A Robertson; Jeffrey P Kahn; John E Wagner
Journal:  Hastings Cent Rep       Date:  2002 May-Jun       Impact factor: 2.683

4.  The value of children: theory and method.

Authors:  J T Fawcett; F S Arnold
Journal:  Represent Res Soc Psychol       Date:  1973-01

Review 5.  Ethics of using preimplantation genetic diagnosis to select a stem cell donor for an existing person.

Authors:  R J Boyle; J Savulescu
Journal:  BMJ       Date:  2001-11-24

6.  Preparing children to be bone marrow donors.

Authors:  Sue P Heiney; Lisa H Bryant; Kamar Godder; Jill Michaels
Journal:  Oncol Nurs Forum       Date:  2002 Nov-Dec       Impact factor: 2.172

7.  Healthy sibling donor anxiety and pain during bone marrow or peripheral blood stem cell harvesting for allogeneic transplantation: results of a randomised study.

Authors:  C Fortanier; M Kuentz; L Sutton; N Milpied; M Michalet; G Macquart-Moulin; C Faucher; A G Le Corroller; J P Moatti; D Blaise
Journal:  Bone Marrow Transplant       Date:  2002-01       Impact factor: 5.483

Review 8.  Ethical considerations on preimplantation genetic diagnosis for HLA typing to match a future child as a donor of haematopoietic stem cells to a sibling.

Authors:  G Pennings; R Schots; I Liebaers
Journal:  Hum Reprod       Date:  2002-03       Impact factor: 6.918

Review 9.  Psychosocial impact of pediatric BMT on siblings.

Authors:  W Packman
Journal:  Bone Marrow Transplant       Date:  1999-10       Impact factor: 5.483

10.  Fetal HLA typing in beta thalassaemia: implications for haemopoietic stem-cell transplantation.

Authors:  Maria Grazia Orofino; Francesca Argiolu; Maria Adele Sanna; Maria Cristina Rosatelli; Teresa Tuveri; Maria Teresa Scalas; Manuela Badiali; Paola Cossu; Rosalba Puddu; Maria Eliana Lai; Antonio Cao
Journal:  Lancet       Date:  2003-07-05       Impact factor: 79.321

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  5 in total

1.  Singling out genetic disorders and disease.

Authors:  Martine De Rycke
Journal:  Genome Med       Date:  2010-10-06       Impact factor: 11.117

2.  Comparing Non-Medical Sex Selection and Saviour Sibling Selection in the Case of JS and LS v Patient Review Panel: Beyond the Welfare of the Child?

Authors:  Malcolm K Smith; Michelle Taylor-Sands
Journal:  J Bioeth Inq       Date:  2018-02-02       Impact factor: 1.352

3.  Conception of Saviour Siblings: Ethical Perceptions of Selected Stakeholders in Malaysia.

Authors:  Chee Ying Kuek; Sharon Kaur A/P Gurmukh Singh; Pek San Tay
Journal:  Asian Bioeth Rev       Date:  2021-03-17

4.  First experience of hematopoietic stem cell transplantation treatment of Shwachman-Diamond syndrome using unaffected HLA-matched sibling donor produced through preimplantation HLA typing.

Authors:  A A Isaev; R V Deev; A Kuliev; I L Plaxa; N V Stancheva; A S Borovkova; I V Potapov; E A Pomerantseva; A G Chogovadze; K Y Boyarsky; A E Semenenko; A V Mikhailov; K G Shevchenko; A V Prikhodko; S Rechitsky; O V Paina; I M Barchatov; L S Zubarovskaya; O Verlinsky; I Y Bozo; B V Afanasyev
Journal:  Bone Marrow Transplant       Date:  2017-03-27       Impact factor: 5.483

5.  Born to donate: proposals for "savior sibling" regulation in Latin America.

Authors:  Alejandra Zúñiga-Fajuri
Journal:  Colomb Med (Cali)       Date:  2018-09-30
  5 in total

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