Literature DB >> 16199106

Effect of enzymatic degradation on the release kinetics of model drug from Pluronic F127/poly(lactic acid) nano-particles.

X Y Xiong1, K C Tam, L H Gan.   

Abstract

Poly(lactic acid) (PLA) was successfully grafted to both ends of Pluronic F127 block copolymer (PEO-PPO-PEO) to obtain amphiphilic PLA-F127-PLA block copolymers. The effect of enzymatic degradation on the release behaviors of hydrophobic model drug 9-(methylaminomethyl)anthracene (MAMA) from PLA-F127-PLA nano-particles with vesicular structure was studied by UV-Vis spectroscopy. It was observed that the release rate of MAMA from PLA-F127-PLA nano-particles with the enzymatic degradation varied with temperature due to the activity of the enzyme with temperature. However, the enzyme concentration has negligible effect on the release rates of MAMA.

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Year:  2005        PMID： 16199106     DOI： 10.1016/j.jconrel.2005.08.005

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  5 in total

Review 1.  Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers.

Authors:  Mary Caldorera-Moore; Nathalie Guimard; Li Shi; Krishnendu Roy
Journal:  Expert Opin Drug Deliv       Date:  2010-04       Impact factor: 6.648

2.  Degradability of poly(lactic acid)-containing nanoparticles: enzymatic access through a cross-linked shell barrier.

Authors:  Sandani Samarajeewa; Ritu Shrestha; Yali Li; Karen L Wooley
Journal:  J Am Chem Soc       Date:  2011-12-13       Impact factor: 15.419

3.  Loading PEG-catalase into filamentous and spherical polymer nanocarriers.

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Journal:  Pharm Res       Date:  2008-10-28       Impact factor: 4.200

4.  Combination Chemotherapy with Cisplatin and Chloroquine: Effect of Encapsulation in Micelles Formed by Self-Assembling Hybrid Dendritic-Linear-Dendritic Block Copolymers.

Authors:  Rebeca González-Pastor; Alexandre Lancelot; Violeta Morcuende-Ventura; María San Anselmo; Teresa Sierra; José L Serrano; Pilar Martin-Duque
Journal:  Int J Mol Sci       Date:  2021-05-14       Impact factor: 5.923

5.  Silver sulfadiazine nanosuspension-loaded thermosensitive hydrogel as a topical antibacterial agent.

Authors:  Xiaoya Liu; Hui Gan; Chaoran Hu; Wenzhong Sun; Xiaoxia Zhu; Zhiyun Meng; Ruolan Gu; Zhuona Wu; Guifang Dou
Journal:  Int J Nanomedicine       Date:  2018-12-28
  5 in total

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