AIMS: Extracellular matrix (ECM) turnover is a major determinant of diastolic dysfunction and pumping capacity, thus potentially contributing to the progression of congestive heart failure (CHF). Patients with both arterial hypertension and diabetes have a high risk of heart failure. Whether these patients have changes in cardiac ECM has not been studied previously. Our objective was to compare blood markers of collagen turnover among patients with CHF, patients with hypertension and type II diabetes (HD), and healthy individuals. METHODS AND RESULTS: Measurements were performed in 239 CHF patients; 64 HD patients and 92 healthy subjects. We showed by adjusted ANOVA that PIIINP levels were significantly higher in CHF and HD patients than in controls, and higher in CHF patients than in HD patients. MMP1 levels were significantly lower in CHF and HD patients than in controls. Collagen type I markers (PICP and PINP) were not influenced by CHF but were lower in HD patients as compared to controls (p<0.05 for all comparisons). CONCLUSION: In heart failure, markers of cardiac collagen synthesis are increased and markers of degradation are decreased, potentially contributing to cardiac fibrosis and thus to poor outcome. Changes in collagen turnover may also occur early in the disease process in high-risk patients before heart failure is clinically detectable.
AIMS: Extracellular matrix (ECM) turnover is a major determinant of diastolic dysfunction and pumping capacity, thus potentially contributing to the progression of congestive heart failure (CHF). Patients with both arterial hypertension and diabetes have a high risk of heart failure. Whether these patients have changes in cardiac ECM has not been studied previously. Our objective was to compare blood markers of collagen turnover among patients with CHF, patients with hypertension and type II diabetes (HD), and healthy individuals. METHODS AND RESULTS: Measurements were performed in 239 CHFpatients; 64 HDpatients and 92 healthy subjects. We showed by adjusted ANOVA that PIIINP levels were significantly higher in CHF and HDpatients than in controls, and higher in CHFpatients than in HDpatients. MMP1 levels were significantly lower in CHF and HDpatients than in controls. Collagen type I markers (PICP and PINP) were not influenced by CHF but were lower in HDpatients as compared to controls (p<0.05 for all comparisons). CONCLUSION: In heart failure, markers of cardiac collagen synthesis are increased and markers of degradation are decreased, potentially contributing to cardiac fibrosis and thus to poor outcome. Changes in collagen turnover may also occur early in the disease process in high-risk patients before heart failure is clinically detectable.
Authors: Raghava S Velagaleti; Philimon Gona; Johan Sundström; Martin G Larson; Deborah Siwik; Wilson S Colucci; Emelia J Benjamin; Ramachandran S Vasan Journal: Arterioscler Thromb Vasc Biol Date: 2010-08-26 Impact factor: 8.311
Authors: Reiner Füth; Wilfried Dinh; Werner Nickl; Lars Bansemir; Michael Coll Barroso; Alexander Bufe; Armin Sause; Thomas Scheffold; Thomas Krahn; Peter Ellinghaus; Mark Lankisch Journal: Exp Clin Cardiol Date: 2009
Authors: Jean Marie Ruddy; Jeffrey A Jones; Robert E Stroud; Rupak Mukherjee; Francis G Spinale; John S Ikonomidis Journal: J Surg Res Date: 2009-01-24 Impact factor: 2.192
Authors: Kalkidan Bishu; Anita Deswal; Horng H Chen; Martin M LeWinter; Gregory D Lewis; Marc J Semigran; Barry A Borlaug; Steven McNulty; Adrian F Hernandez; Eugene Braunwald; Margaret M Redfield Journal: Am Heart J Date: 2012-10-16 Impact factor: 4.749