Literature DB >> 16198446

Inflammation, the complement system and the diseases of aging.

Edith G McGeer1, Andis Klegeris, Patrick L McGeer.   

Abstract

Inflammation is characteristic of neurodegenerative diseases of aging. Neuropathological evidence of activated microglia and activated astrocytes in lesioned areas, combined with epidemiological evidence of sparing of Alzheimer's disease (AD), Parkinson's disease (PD) and age-related macular degeneration (AMD) in long-term users of anti-inflammatory agents, indicates that inflammation is autodestructive of neurons. Locally produced autodestructive molecules include the membrane attack complex (MAC) of complement and oxygen-free radicals. Stimulation is provided by a variety of inflammatory cytokines. Agents which reduce the intensity of inflammation should have broad spectrum application in degenerative diseases of aging.

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Year:  2005        PMID： 16198446     DOI： 10.1016/j.neurobiolaging.2005.08.008

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  76 in total

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Authors:  O I Schmidt; I Leinhase; E Hasenboehler; S J Morgan; P F Stahel
Journal:  Orthopade       Date:  2007-03       Impact factor: 1.087

2.  Role of complement cascade in abdominal aortic aneurysms.

Authors:  Irene Hinterseher; Robert Erdman; Larry A Donoso; Tamara R Vrabec; Charles M Schworer; John H Lillvis; Amy M Boddy; Kimberly Derr; Alicia Golden; William D Bowen; Zoran Gatalica; Nikos Tapinos; James R Elmore; David P Franklin; John L Gray; Robert P Garvin; Glenn S Gerhard; David J Carey; Gerard Tromp; Helena Kuivaniemi
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3.  Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.

Authors:  Liya Qin; Xuefei Wu; Michelle L Block; Yuxin Liu; George R Breese; Jau-Shyong Hong; Darin J Knapp; Fulton T Crews
Journal:  Glia       Date:  2007-04-01       Impact factor: 7.452

4.  Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease.

Authors:  Gillian Hamilton; Petra Proitsi; Julie Williams; Michael O'Donovan; Michael Owen; John Powell; Simon Lovestone
Journal:  Neuromolecular Med       Date:  2007-09-22       Impact factor: 3.843

Review 5.  Chemiexcitation and Its Implications for Disease.

Authors:  Douglas E Brash; Leticia C P Goncalves; Etelvino J H Bechara
Journal:  Trends Mol Med       Date:  2018-05-08       Impact factor: 11.951

Review 6.  Parkinson's disease.

Authors:  Timothy R Mhyre; James T Boyd; Robert W Hamill; Kathleen A Maguire-Zeiss
Journal:  Subcell Biochem       Date:  2012

7.  Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status.

Authors:  Martha Savaria Morris; Lydia Sakakeeny; Paul F Jacques; Mary Frances Picciano; Jacob Selhub
Journal:  J Nutr       Date:  2009-11-11       Impact factor: 4.798

8.  Parkin negatively regulates the antiviral signaling pathway by targeting TRAF3 for degradation.

Authors:  Di Xin; Haiyan Gu; Enping Liu; Qinmiao Sun
Journal:  J Biol Chem       Date:  2018-06-14       Impact factor: 5.157

Review 9.  CD4 T cells in immunity and immunotherapy of Alzheimer's disease.

Authors:  Alon Monsonego; Anna Nemirovsky; Idan Harpaz
Journal:  Immunology       Date:  2013-08       Impact factor: 7.397

10.  Paeonol Suppresses Neuroinflammatory Responses in LPS-Activated Microglia Cells.

Authors:  Li Xia He; Xiaoyun Tong; Jing Zeng; Yuanqing Tu; Saicun Wu; Manping Li; Huaming Deng; Miaomiao Zhu; Xiucun Li; Hong Nie; Li Yang; Feng Huang
Journal:  Inflammation       Date:  2016-12       Impact factor: 4.092
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