Literature DB >> 16198156

A new SUMO ligase in the DNA damage response.

Karen M Lee1, Matthew J O'Connell.   

Abstract

SUMO is a small ubiquitin-like protein that is attached to target proteins, altering their localization and function. The condensin and cohesin-related Smc5/6 complex has been linked to DNA repair and checkpoint responses, but details of its molecular function have remained obscure. Recent reports show one subunit of the complex is a SUMO ligase, providing another link between protein sumoylation and DNA damage responses.

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Year:  2005        PMID: 16198156     DOI: 10.1016/j.dnarep.2005.08.003

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN: 1568-7856


  6 in total

Review 1.  Functional interplay between cohesin and Smc5/6 complexes.

Authors:  Claudia Tapia-Alveal; Su-Jiun Lin; Matthew J O'Connell
Journal:  Chromosoma       Date:  2014-07-01       Impact factor: 4.316

2.  Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6.

Authors:  Xinyuan Duan; Yan Yang; Yu-Hung Chen; Jacqueline Arenz; Gurdish K Rangi; Xiaolan Zhao; Hong Ye
Journal:  J Biol Chem       Date:  2009-01-13       Impact factor: 5.157

3.  SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.

Authors:  Johanna Heideker; John Prudden; J Jefferson P Perry; John A Tainer; Michael N Boddy
Journal:  PLoS Genet       Date:  2011-03-03       Impact factor: 5.917

4.  SUMO-1 regulates the conformational dynamics of thymine-DNA Glycosylase regulatory domain and competes with its DNA binding activity.

Authors:  Caroline Smet-Nocca; Jean-Michel Wieruszeski; Hélène Léger; Sebastian Eilebrecht; Arndt Benecke
Journal:  BMC Biochem       Date:  2011-02-01       Impact factor: 4.059

5.  PIASgamma is required for faithful chromosome segregation in human cells.

Authors:  Laura A Díaz-Martínez; Juan F Giménez-Abián; Yoshiaki Azuma; Vincent Guacci; Gonzalo Giménez-Martín; Lorene M Lanier; Duncan J Clarke
Journal:  PLoS One       Date:  2006-12-20       Impact factor: 3.240

6.  Emerging roles of the SUMO pathway in mitosis.

Authors:  Mary Dasso
Journal:  Cell Div       Date:  2008-01-24       Impact factor: 5.130

  6 in total

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