Literature DB >> 16195925

Canards for a reduction of the Hodgkin-Huxley equations.

Jeff Moehlis1.   

Abstract

This paper shows that canards, which are periodic orbits for which the trajectory follows both the attracting and repelling part of a slow manifold, can exist for a two-dimensional reduction of the Hodgkin-Huxley equations. Such canards are associated with a dramatic change in the properties of the periodic orbit within a very narrow interval of a control parameter. By smoothly connecting stable and unstable manifolds in an asymptotic limit, we predict with great accuracy the parameter value at which the canards exist for this system. This illustrates the power of using singular perturbation theory to understand the dynamical properties of realistic biological systems.

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Year:  2005        PMID: 16195925     DOI: 10.1007/s00285-005-0347-1

Source DB:  PubMed          Journal:  J Math Biol        ISSN: 0303-6812            Impact factor:   2.164


  2 in total

1.  A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors:  A L HODGKIN; A F HUXLEY
Journal:  J Physiol       Date:  1952-08       Impact factor: 5.182

2.  Excitation dynamics: insights from simplified membrane models.

Authors:  J Rinzel
Journal:  Fed Proc       Date:  1985-12
  2 in total
  10 in total

1.  Geometric singular perturbation theory in biological practice.

Authors:  Geertje Hek
Journal:  J Math Biol       Date:  2009-04-05       Impact factor: 2.259

2.  New dynamics in cerebellar Purkinje cells: torus canards.

Authors:  Mark A Kramer; Roger D Traub; Nancy J Kopell
Journal:  Phys Rev Lett       Date:  2008-08-08       Impact factor: 9.161

3.  Inflection, canards and excitability threshold in neuronal models.

Authors:  M Desroches; M Krupa; S Rodrigues
Journal:  J Math Biol       Date:  2012-09-04       Impact factor: 2.259

4.  Minimum energy desynchronizing control for coupled neurons.

Authors:  Ali Nabi; Mohammad Mirzadeh; Frederic Gibou; Jeff Moehlis
Journal:  J Comput Neurosci       Date:  2012-08-18       Impact factor: 1.621

5.  Role of intraglomerular circuits in shaping temporally structured responses to naturalistic inhalation-driven sensory input to the olfactory bulb.

Authors:  Ryan M Carey; William Erik Sherwood; Michael T Shipley; Alla Borisyuk; Matt Wachowiak
Journal:  J Neurophysiol       Date:  2015-02-25       Impact factor: 2.714

6.  Clustered Desynchronization from High-Frequency Deep Brain Stimulation.

Authors:  Dan Wilson; Jeff Moehlis
Journal:  PLoS Comput Biol       Date:  2015-12-29       Impact factor: 4.475

7.  Inferring Neuronal Dynamics from Calcium Imaging Data Using Biophysical Models and Bayesian Inference.

Authors:  Vahid Rahmati; Knut Kirmse; Dimitrije Marković; Knut Holthoff; Stefan J Kiebel
Journal:  PLoS Comput Biol       Date:  2016-02-19       Impact factor: 4.475

8.  From Squid to Mammals with the HH Model through the Nav Channels' Half-Activation-Voltage Parameter.

Authors:  Nedialko I Krouchev; Frank Rattay; Mohamad Sawan; Alain Vinet
Journal:  PLoS One       Date:  2015-12-02       Impact factor: 3.240

Review 9.  Classification of bursting patterns: A tale of two ducks.

Authors:  Mathieu Desroches; John Rinzel; Serafim Rodrigues
Journal:  PLoS Comput Biol       Date:  2022-02-24       Impact factor: 4.475

10.  Cross-scale excitability in networks of quadratic integrate-and-fire neurons.

Authors:  Daniele Avitabile; Mathieu Desroches; G Bard Ermentrout
Journal:  PLoS Comput Biol       Date:  2022-10-03       Impact factor: 4.779

  10 in total

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