Literature DB >> 16195922

A new modeling approach to the effect of antimicrobial agents on heterogeneous microbial populations.

Michael Nikolaou1, Vincent H Tam.   

Abstract

We develop a mathematical framework to model the dynamics of the effect of antimicrobial agents on heterogeneous microbial populations of distributed antimicrobial resistance. Our framework uses the concept of cumulants of a distribution. Simplifications that result in easily usable approximation tools are presented. A case study on experimental data exemplifies shortcomings of standard methods and the usefulness of the proposed approach. Suggestions for future development are made.

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Year:  2005        PMID： 16195922     DOI： 10.1007/s00285-005-0350-6

Source DB:  PubMed          Journal:  J Math Biol        ISSN： 0303-6812            Impact factor:   2.164


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