Literature DB >> 16195804

Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches.

Brian R Rood1, Tobey J MacDonald.   

Abstract

High grade glioma remains the most intractable childhood tumor of the central nervous system. The molecular genetics of childhood high grade glioma remain largely unknown in comparison to that of their adult counterparts. In an era of molecularly targeted therapies, this dearth of knowledge will present particular challenges to those who must design and implement the next generation of therapeutic trials with these new agents. In this review, we discuss the current understanding of the molecular genetics of childhood high grade glioma and compare/contrast it to that of the adult tumors bearing the same classification for the purpose of beginning to identify the most promising therapeutic targets.

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Year:  2005        PMID： 16195804     DOI： 10.1007/s11060-005-6749-5

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  49 in total

1.  Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations.

Authors:  C Raffel; L Frederick; J R O'Fallon; P Atherton-Skaff; A Perry; R B Jenkins; C D James
Journal:  Clin Cancer Res       Date:  1999-12       Impact factor: 12.531

2.  Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood.

Authors:  M Bredel; I F Pollack; R L Hamilton; C D James
Journal:  Clin Cancer Res       Date:  1999-07       Impact factor: 12.531

3.  Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients.

Authors:  M L Simmons; K R Lamborn; M Takahashi; P Chen; M A Israel; M S Berger; T Godfrey; J Nigro; M Prados; S Chang; F G Barker; K Aldape
Journal:  Cancer Res       Date:  2001-02-01       Impact factor: 12.701

4.  A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities.

Authors:  P G Fisher; S N Breiter; B S Carson; M D Wharam; J A Williams; J D Weingart; D R Foer; P T Goldthwaite; T Tihan; P C Burger
Journal:  Cancer       Date:  2000-10-01       Impact factor: 6.860

5.  Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.

Authors:  T Warr; S Ward; J Burrows; B Harding; P Wilkins; W Harkness; R Hayward; J Darling; D Thomas
Journal:  Genes Chromosomes Cancer       Date:  2001-05       Impact factor: 5.006

6.  Molecular genetic changes in a series of neuroepithelial tumors of childhood.

Authors:  Alessia Di Sapio; Isabella Morra; Luca Pradotto; Marilena Guido; Davide Schiffer; Alessandro Mauro
Journal:  J Neurooncol       Date:  2002-09       Impact factor: 4.130

7.  Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes.

Authors:  E W Newcomb; H Cohen; S R Lee; S K Bhalla; J Bloom; R L Hayes; D C Miller
Journal:  Brain Pathol       Date:  1998-10       Impact factor: 6.508

8.  Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas.

Authors:  M Hermanson; K Funa; J Koopmann; D Maintz; A Waha; B Westermark; C H Heldin; O D Wiestler; D N Louis; A von Deimling; M Nistér
Journal:  Cancer Res       Date:  1996-01-01       Impact factor: 12.701

9.  Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme.

Authors:  Naoki Shinojima; Kenji Tada; Shoji Shiraishi; Takanori Kamiryo; Masato Kochi; Hideo Nakamura; Keishi Makino; Hideyuki Saya; Hirofumi Hirano; Jun-Ichi Kuratsu; Koji Oka; Yasuji Ishimaru; Yukitaka Ushio
Journal:  Cancer Res       Date:  2003-10-15       Impact factor: 12.701

10.  Microsatellite instability and expression of DNA mismatch repair genes in malignant astrocytic tumors from adult and pediatric patients.

Authors:  M Szybka; J Bartkowiak; K Zakrzewski; L Polis; P Liberski; R Kordek
Journal:  Clin Neuropathol       Date:  2003 Jul-Aug       Impact factor: 1.368
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  17 in total

1.  Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas.

Authors:  Manila Antonelli; Francesca Romana Buttarelli; Antonietta Arcella; Sumihito Nobusawa; Vittoria Donofrio; Hiroko Oghaki; Felice Giangaspero
Journal:  J Neurooncol       Date:  2010-02-21       Impact factor: 4.130

2.  Glioblastoma multiforme: Molecular characterization and current treatment strategy (Review).

Authors:  Xiang Zhang; Wei Zhang; Wei-Dong Cao; Gang Cheng; Yong-Qiang Zhang
Journal:  Exp Ther Med       Date:  2011-10-18       Impact factor: 2.447

3.  Clinical and molecular characteristics of congenital glioblastoma.

Authors:  Margaret E Macy; Diane K Birks; Valerie N Barton; Michael H Chan; Andrew M Donson; B K Kleinschmidt-Demasters; Lynne T Bemis; Michael H Handler; Nicholas K Foreman
Journal:  Neuro Oncol       Date:  2012-06-18       Impact factor: 12.300

4.  Impact of molecular biology studies on the understanding of brain tumors in childhood.

Authors:  Amulya A Nageswara Rao; Roger J Packer
Journal:  Curr Oncol Rep       Date:  2012-04       Impact factor: 5.075

5.  Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas.

Authors:  Hui-Qi Qu; Karine Jacob; Sarah Fatet; Bing Ge; David Barnett; Olivier Delattre; Damien Faury; Alexandre Montpetit; Lauren Solomon; Peter Hauser; Miklos Garami; Laszlo Bognar; Zoltan Hansely; Robert Mio; Jean-Pierre Farmer; Steffen Albrecht; Constantin Polychronakos; Cynthia Hawkins; Nada Jabado
Journal:  Neuro Oncol       Date:  2009-10-15       Impact factor: 12.300

6.  Mesenchymal migration as a therapeutic target in glioblastoma.

Authors:  Jessie Zhong; Andre Paul; Stewart J Kellie; Geraldine M O'Neill
Journal:  J Oncol       Date:  2010-06-21       Impact factor: 4.375

7.  Outcome of young children with high-grade glioma treated with irradiation-avoiding intensive chemotherapy regimens: Final report of the Head Start II and III trials.

Authors:  Juan C Espinoza; Kelley Haley; Neha Patel; Girish Dhall; Sharon Gardner; Jeffrey Allen; Joseph Torkildson; Albert Cornelius; Rod Rassekh; Antranik Bedros; Morris Etzl; James Garvin; Kamnesh Pradhan; Robin Corbett; Michael Sullivan; Geoffrey McGowage; Dagmar Stein; Rama Jasty; Stephen A Sands; Lingyun Ji; Richard Sposto; Jonathan L Finlay
Journal:  Pediatr Blood Cancer       Date:  2016-06-22       Impact factor: 3.167

8.  Modeling Adult Gliomas Using RCAS/t-va Technology.

Authors:  Dolores Hambardzumyan; Nduka M Amankulor; Karim Y Helmy; Oren J Becher; Eric C Holland
Journal:  Transl Oncol       Date:  2009-05       Impact factor: 4.243

9.  Pharmacokinetics of erlotinib for the treatment of high-grade glioma in a pediatric patient with cystic fibrosis: case report and review of the literature.

Authors:  Shannon R Christiansen; Alberto Broniscer; J Carl Panetta; Clinton F Stewart
Journal:  Pharmacotherapy       Date:  2009-07       Impact factor: 4.705

10.  Clinical outcome and molecular characterization of pediatric glioblastoma treated with postoperative radiotherapy with concurrent and adjuvant temozolomide: a single institutional study of 66 children.

Authors:  Rakesh Jalali; Anupam Rishi; Jayant S Goda; Epari Sridhar; Mamta Gurav; Pravin Sharma; Aliasgar Moiyadi; Prakash Shetty; Tejpal Gupta
Journal:  Neurooncol Pract       Date:  2015-08-06
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