| Literature DB >> 16195558 |
Jason Phan1, Brian P Austin, David S Waugh.
Abstract
The plague-causing bacterium Yersinia pestis utilizes a contact-dependent (type III) secretion system (T3SS) to transport virulence factors from the bacterial cytosol directly into the interior of mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. The type III secretion apparatus is composed of 20-25 different Yersinia secretion (Ysc) proteins. We report here the structure of YscE, the smallest Ysc protein, which is a dimer in solution. The probable mode of oligomerization is discussed.Entities:
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Year: 2005 PMID: 16195558 PMCID: PMC2253283 DOI: 10.1110/ps.051706105
Source DB: PubMed Journal: Protein Sci ISSN: 0961-8368 Impact factor: 6.725