OBJECTIVE: Endothelin-1 (ET-1) is postulated to play an important role in the development of cerebral vasospasm (CVS) following SAH. This study was conducted to investigate the time course of ET-release in three different sources: CSF, plasma and microdialysate. METHODS: In a prospective study ET-1-concentrations were measured in plasma, cisternal CSF and microdialysate in 20 patients with aneurysmal SAH for at least 8 days after hemorrhage. RESULTS: ET-1 concentration in microdialysate was almost four times higher compared to CSF and plasma. (p<0.001) Only in CSF ET-1-release showed a significant increase over time with highest values on day 5 post ictus (p = 0.03). This was parallel to the increase of transcranial Doppler velocities. ET-1 in plasma and microdialysate did not change over time. CONCLUSION: ET-1 may have a different biological function in different biological tissues. Only ET-1 in CSF seemed to be associated with CVS.
OBJECTIVE:Endothelin-1 (ET-1) is postulated to play an important role in the development of cerebral vasospasm (CVS) following SAH. This study was conducted to investigate the time course of ET-release in three different sources: CSF, plasma and microdialysate. METHODS: In a prospective study ET-1-concentrations were measured in plasma, cisternal CSF and microdialysate in 20 patients with aneurysmalSAH for at least 8 days after hemorrhage. RESULTS:ET-1 concentration in microdialysate was almost four times higher compared to CSF and plasma. (p<0.001) Only in CSFET-1-release showed a significant increase over time with highest values on day 5 post ictus (p = 0.03). This was parallel to the increase of transcranial Doppler velocities. ET-1 in plasma and microdialysate did not change over time. CONCLUSION:ET-1 may have a different biological function in different biological tissues. Only ET-1 in CSF seemed to be associated with CVS.
Authors: Ana I Oliveira-Ferreira; Denny Milakara; Mesbah Alam; Devi Jorks; Sebastian Major; Jed A Hartings; Janos Lückl; Peter Martus; Rudolf Graf; Christian Dohmen; Georg Bohner; Johannes Woitzik; Jens P Dreier Journal: J Cereb Blood Flow Metab Date: 2010-03-24 Impact factor: 6.200
Authors: Bhavani P Thampatty; Paula R Sherwood; Matthew J Gallek; Elizabeth A Crago; Dianxu Ren; Allison J Hricik; Chien-Wen J Kuo; Megan M Klamerus; Sheila A Alexander; Catherine M Bender; Leslie A Hoffman; Michael B Horowitz; Amin B Kassam; Samuel M Poloyac Journal: Neurocrit Care Date: 2011-08 Impact factor: 3.210
Authors: Rosanne Salonia; Philip E Empey; Samuel M Poloyac; Stephen R Wisniewski; Megan Klamerus; Haishin Ozawa; Amy K Wagner; Randall Ruppel; Michael J Bell; Keri Feldman; P David Adelson; Robert S B Clark; Patrick M Kochanek Journal: J Neurotrauma Date: 2010-09-17 Impact factor: 5.269
Authors: Doris A Chatfield; Darshan H Brahmbhatt; Tilly Sharp; Iain E Perkes; Joanne G Outrim; David K Menon Journal: Neurocrit Care Date: 2011-02 Impact factor: 3.210