| Literature DB >> 16193126 |
Søren Bertelsen1, Nis Halland, Stephan Bachmann, Mauro Marigo, Alan Braunton, Karl Anker Jørgensen.
Abstract
The first organocatalytic enantioselective alpha-bromination of aldehydes and ketones is presented; a C2-symmetric diphenylpyrrolidine catalyst afforded the alpha-brominated aldehydes in good yields and up to 96% ee, while ketones were alpha-brominated by a C2-symmetric imidazolidine in up to 94% ee; furthermore, the organocatalytic enantioselective alpha-iodination of aldehydes is also demonstrated to proceed with up to 89% ee.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16193126 DOI： 10.1039/b509366j
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222