Literature DB >> 16193085

FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma.

G Roncador1, J F Garcia, J F Garcia, L Maestre, E Lucas, J Menarguez, K Ohshima, S Nakamura, A H Banham, M A Piris.   

Abstract

FOXP3 is a forkhead transcription factor family member, implicated in T-cell regulation, activation and differentiation. FOXP3 has been shown to be a master control gene for the development and function of CD4+/CD25+ regulatory T-cells (T(reg)). In this study, FOXP3 protein expression has been analysed using a new anti-FOXP3 monoclonal antibody in 172 paraffin-embedded lymphoma samples. FOXP3 expression in tumour cells was confined to adult T-cell leukaemia/lymphoma (ATLL) cases (17/25, 68%), with some variability in the intensity of the staining and the proportion of positive cells. No other lymphoma types studied exhibited FOXP3 expression in the malignant population. The selective expression of FOXP3 by tumour cells in ATLL makes this antibody a potentially useful diagnostic tool.

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Year:  2005        PMID： 16193085     DOI： 10.1038/sj.leu.2403965

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  29 in total

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2.  The role of FOXP3 rs3761548 and rs2294021 polymorphisms in pediatrics acute lymphoblastic leukemia: association with risk and response to therapy.

Authors:  Zahra Ghasemi; Kurosh Kalantar; Zahra Amirghofran
Journal:  Mol Biol Rep       Date:  2021-01-30       Impact factor: 2.316

3.  FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.

Authors:  V Fleskens; M Mokry; A M van der Leun; S Huppelschoten; C E G M Pals; J Peeters; S Coenen; B A Cardoso; J T Barata; J van Loosdregt; P J Coffer
Journal:  Oncogene       Date:  2015-12-21       Impact factor: 9.867

4.  Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients.

Authors:  Mariana Tomazini Pinto; Tathiane Maistro Malta; Evandra Strazza Rodrigues; Daniel Guariz Pinheiro; Rodrigo Alexandre Panepucci; Kelen Cristina Ribeiro Malmegrim de Farias; Alessandra De Paula Sousa; Osvaldo Massaiti Takayanagui; Yuetsu Tanaka; Dimas Tadeu Covas; Simone Kashima
Journal:  AIDS Res Hum Retroviruses       Date:  2013-10-16       Impact factor: 2.205

5.  Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma.

Authors:  Elisabetta Capriotti; Eric C Vonderheid; Christopher J Thoburn; Mariusz A Wasik; David W Bahler; Allan D Hess
Journal:  Leuk Lymphoma       Date:  2008-06

6.  Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice.

Authors:  Jinlin Liu; Ning Zhang; Qun Li; Weiwei Zhang; Fang Ke; Qibin Leng; Hong Wang; Jinfei Chen; Honglin Wang
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240

Review 7.  Adult T-cell leukemia/lymphoma accompanying follicular mucinosis: a case report with review of the literature.

Authors:  Mitsuaki Ishida; Muneo Iwai; Keiko Yoshida; Akiko Kagotani; Hidetoshi Okabe
Journal:  Int J Clin Exp Pathol       Date:  2013-11-15

8.  Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2.

Authors:  Kerrington R Molhoek; Chantel C McSkimming; Walter C Olson; David L Brautigan; Craig L Slingluff
Journal:  Cancer Immunol Immunother       Date:  2008-10-08       Impact factor: 6.968

9.  Animals Models of Human T Cell Leukemia Virus Type I Leukemogenesis.

Authors:  Stefan Niewiesk
Journal:  ILAR J       Date:  2016

10.  Paucity of intraepidermal FoxP3-positive T cells in cutaneous T-cell lymphoma in contrast with spongiotic and lichenoid dermatitis.

Authors:  David A Wada; Ryan A Wilcox; Roger H Weenig; Lawrence E Gibson
Journal:  J Cutan Pathol       Date:  2009-08-07       Impact factor: 1.587
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